Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.51 |
| ▸ | SI | P14410 | 1/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719399 | 0.83 | GAA (0.51) | GAAMGAMSIMGAM2SCD | |
| SCHEMBL694906 | 0.82 | NPC1 (0.62) | GAAPARP1NPC1RAB9AKDM4E | |
| SCHEMBL7395100 | 0.80 | KDM4E (0.67) | GAAMGAMSIMGAM2PTPN1 | |
| SCHEMBL2078169 | 0.79 | KDM4E (0.38) | GAANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7396441 | 0.75 | KDM4E (0.54) | GAAMGAMSIMGAM2PTPN1 | |
| SCHEMBL2124653 | 0.75 | KDM4E (0.66) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL693773 | 0.75 | ALDH1A1 (0.43) | GAANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7429659 | 0.75 | MGAM (0.52) | GAAMGAMSIMGAM2PTPN1 | |
| SCHEMBL6282502 | 0.75 | GAA (0.53) | GAAMGAMSIMGAM2PTPN1 | |
| SCHEMBL10742498 | 0.75 | GAA (0.55) | GAAMGAMSIMGAM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |