Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.51 |
| ▸ | SI | P14410 | 1/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324234 | 0.90 | NPC1 (0.62) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL5579984 | 0.86 | CHEK1 (0.59) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL28640195 | 0.85 | KDM4E (0.73) | MEN1KMT2APOLBNPC1RAB9A | |
| SCHEMBL14601535 | 0.85 | AMY1A (0.51) | GAAMEN1KMT2AUSP2NPC1 | |
| SCHEMBL57009 | 0.84 | POLB (0.57) | GAAMEN1KMT2APOLBUSP2 | |
| SCHEMBL7396441 | 0.83 | KDM4E (0.54) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7395100 | 0.81 | KDM4E (0.67) | GAAMEN1KMT2APOLBUSP2 | |
| SCHEMBL4495899 | 0.81 | AMY1A (0.53) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL16147536 | 0.81 | NPC1 (0.57) | GAAMEN1KMT2APOLBNPC1 | |
| SCHEMBL19994515 | 0.79 | KDM4E (0.65) | GAAMEN1KMT2APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511744-A2 | BIS-BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS | Icagen, Inc. (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003094861-A2 | BIS-BENZIMIDAZOLES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2003-11-20 | — | — | WO | disclosed |