Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 4/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16699674 | 0.74 | PLAT (0.34) | PLATPDE4DCYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL16701033 | 0.70 | POLB (0.34) | PLATPDE4DCYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL16711364 | 0.68 | ALDH1A1 (0.32) | PLATPDE4DCYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL16700630 | 0.67 | KMT2A (0.35) | PLATPDE4DCYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL16699032 | 0.66 | ADORA3 (0.37) | PLATPDE4DCYP1A2TSHRHTT | |
| SCHEMBL16711515 | 0.66 | ALDH1A1 (0.33) | PDE4DTSHRSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL16699535 | 0.65 | PDE4D (0.35) | PLATPDE4DCYP1A2TSHRSMN1; SMN2 | |
| SCHEMBL16699755 | 0.64 | PLAT (0.34) | PLATPDE4DCYP1A2SMN1; SMN2HTT | |
| SCHEMBL16711267 | 0.64 | PLAT (0.34) | PLATPDE4DCYP1A2SMN1; SMN2HTT | |
| SCHEMBL16700012 | 0.64 | ALDH1A1 (0.31) | TSHRSMN1; SMN2ALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068784-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | Bristol-Myers Squibb Company (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073767-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |