Sugi Predict

Sugi Predict / Compounds / SCHEMBL167247

SCHEMBL167247

SCHEMBL167247

O=C1CCCc2nc(Cl)sc21

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.61
▸ MAPK1 P28482 1/20 0.61
▸ SMN1; SMN2 Q16637 2/20 0.53
▸ PIK3CD O00329 1/20 0.53
▸ PIK3CA P42336 1/20 0.53
▸ PIK3CB P42338 1/20 0.53
▸ PIK3CG P48736 1/20 0.53
▸ GRM5 P41594 2/20 0.46
▸ NPC1 O15118 2/20 0.43
▸ TP53 P04637 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ MAOA P21397 1/20 0.32
▸ MAOB P27338 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.31
▸ GAA P10253 1/20 0.31
▸ HTT P42858 1/20 0.31
▸ FBP1 P09467 1/20 0.31
▸ PDK1 Q15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL170013 0.76 ALDH1A1 (1.00) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
SCHEMBL2035154 0.76 ALDH1A1 (0.61) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
Hydrochloric Acid SCHEMBL30189955 0.74 ALDH1A1 (0.96) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
Bromide SCHEMBL3450128 0.74 ALDH1A1 (0.96) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
SCHEMBL6118325 0.72 ALDH1A1 (0.56) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
SCHEMBL691842 0.72 ALDH1A1 (0.92) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
SCHEMBL2074118 0.72 GRM5 (0.43) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
SCHEMBL18237867 0.72 ALDH1A1 (0.56) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
SCHEMBL9964551 0.72 ALDH1A1 (0.56) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA
SCHEMBL2854104 0.72 ALDH1A1 (0.56) ALDH1A1MAPK1SMN1; SMN2PIK3CDPIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8304556-B2 Thiazolyl-dihydro-indazoles BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-11-06 — — US disclosed
US-20120129854-A1 Pesticidal Arylpyrrolidines BAYER CROPSCIENCE AG (DE) 2012-05-24 — — US disclosed
US-20120129854-A1 Pesticidal Arylpyrrolidines BAYER CROPSCIENCE AG (DE) 2012-05-24 — — US disclosed
US-20120129854-A1 Pesticidal Arylpyrrolidines BAYER CROPSCIENCE AG (DE) 2012-05-24 — — US disclosed
US-20120108567-A1 Thiazolyl-Dihydro-Indazoles BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-05-03 — — US disclosed
EP-2424838-A1 PESTICIDAL ARYLPYRROLIDINES Bayer CropScience AG (DE) 2012-03-07 — — EP disclosed
US-20110118208-A1 Thiazolyl-Dihydro-Indazoles BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-05-19 — — US disclosed
EP-2280982-A1 THIAZOLYL-DIHYDRO-INDAZOLES Boehringer Ingelheim International GmbH (DE) 2011-02-09 — — EP disclosed
WO-2010124845-A1 PESTICIDAL ARYLPYRROLIDINES BAYER CROPSCIENCE AG (DE) 2010-11-04 — — WO disclosed
WO-2010124845-A1 PESTICIDAL ARYLPYRROLIDINES BAYER CROPSCIENCE AG (DE) 2010-11-04 — — WO disclosed
US-7820837-B2 ethyl {6-[(3-phenoxybenzyl)oxy]-3,4-dihydronaphthalen-1-yl}acetate; having a GPR40 receptor function modulating action and being useful as an insulin secretagogue or a pharmaceutical agent for the prophylaxis or treatment of diabetes TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 — — US disclosed
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands UCB PHARMA, S.A. (BE) 2010-01-14 — — US disclosed
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands UCB PHARMA, S.A. (BE) 2010-01-14 — — US disclosed
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands UCB PHARMA, S.A. (BE) 2010-01-14 — — US disclosed
WO-2009112565-A1 THIAZOLYL-DIHYDRO-INDAZOLES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-09-17 — — WO disclosed
EP-2049548-A1 FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS UCB Pharma, S.A. (BE) 2009-04-22 — — EP disclosed
WO-2008012010-A1 FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS UCB PHARMA, S.A. (BE) 2008-01-31 — — WO disclosed
WO-2008012010-A1 FUSED OXAZOLES & THIAZOLES AS HISTAMINE H3- RECEPTOR LIGANDS UCB PHARMA, S.A. (BE) 2008-01-31 — — WO disclosed
US-20060258722-A1 Condensed ring compound TAKEDA PHARMACEUTICAL COMPANY., LTD. (JP) 2006-11-16 — — US disclosed
EP-1630152-A1 CONDENSED RING COMPOUND Takeda Pharmaceutical Company Limited (JP) 2006-03-01 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120129854-A1 Pesticidal Arylpyrrolidines DDT, AADAC, AHR ALDH1A1 103/4885MAPK1 3593/4885SMN1; SMN2 1921/4885
US-20120108567-A1 Thiazolyl-Dihydro-Indazoles MKI67, CYP11B1, IGF1R ALDH1A1 54/4885MAPK1 962/4885SMN1; SMN2 1428/4885
US-20110118208-A1 Thiazolyl-Dihydro-Indazoles MKI67, CYP11B1, IGF1R ALDH1A1 54/4885MAPK1 962/4885SMN1; SMN2 1428/4885
US-20060258722-A1 Condensed ring compound GPR119, GLP1R, GCGR ALDH1A1 4152/4885MAPK1 762/4885SMN1; SMN2 3722/4885
US-20100009969-A1 Fused Oxazoles & Thiazoles As Histamine H3- Receptor Ligands HRH3, HRH4, HRH2 ALDH1A1 2035/4885MAPK1 3144/4885SMN1; SMN2 4815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.