Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 1/20 | 0.84 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.84 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.84 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | BLM | P54132 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672814 | 1.00 | PRKAG1 (0.84) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL1615003 | 0.91 | PRKAG1 (1.00) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL1615001 | 0.91 | PRKAG1 (1.00) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL29434995 | 0.91 | PRKAG1 (1.00) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL12712488 | 0.80 | AURKA (1.00) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL2834247 | 0.79 | AURKA (0.53) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL2834249 | 0.79 | AURKA (0.53) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL1615171 | 0.79 | PRKAG1 (0.66) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL1669842 | 0.79 | PRKAG1 (0.66) | PRKAG1PRKAA1PRKAB1AURKAMTOR | |
| SCHEMBL1672815 | 0.78 | PRKAG1 (0.64) | PRKAG1PRKAA1PRKAB1AURKAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488027-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | The Ohio State University Research Foundation (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011044548-A1 | THIAZOLIDINEDIONE ENERGY RESTRICTION-MIMETIC AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-04-14 | — | — | WO | claimed |