Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672810 | 0.90 | BRD4 (0.40) | BRD4BRD2MLYCDHDAC6CREBBP | |
| SCHEMBL1672792 | 0.82 | ERN1 (0.38) | BRD4BRD2MLYCDHDAC6 | |
| SCHEMBL1672861 | 0.81 | BRD4 (0.38) | BRD4BRD2MLYCDATAD2JAK2 | |
| SCHEMBL1672863 | 0.81 | BRD4 (0.38) | BRD4BRD2MLYCDATAD2JAK2 | |
| SCHEMBL12800384 | 0.78 | BRD4 (0.39) | BRD4BRD2MLYCDCREBBP | |
| SCHEMBL1670490 | 0.77 | BRD4 (0.35) | BRD4CREBBP | |
| SCHEMBL1670720 | 0.75 | TLR8 (0.39) | BRD4HDAC6 | |
| SCHEMBL12800390 | 0.72 | BRD4 (0.43) | BRD4BRD2MLYCDJAK2CREBBP | |
| SCHEMBL1670736 | 0.72 | BRD4 (0.40) | BRD4BRD2MLYCDHDAC6USP30 | |
| SCHEMBL1672805 | 0.72 | BRD4 (0.38) | BRD4BRD2MLYCDCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | claimed |
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |