Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 4/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1672810 | 0.84 | BRD4 (0.40) | BRD4HSP90AB1ERN1CREBBP | |
| SCHEMBL1672792 | 0.83 | ERN1 (0.38) | BRD4NSD3BCL2L1BAK1ERN1 | |
| SCHEMBL1682601 | 0.83 | HSP90AB1 (0.35) | BRD4HSP90AB1NSD3ESR1BCL2L1 | |
| SCHEMBL1670492 | 0.82 | BRD4 (0.35) | BRD4HSP90AB1NSD3ESR1ESR2 | |
| SCHEMBL1672865 | 0.77 | BRD4 (0.37) | BRD4CREBBP | |
| SCHEMBL21141736 | 0.76 | GPBAR1 (0.37) | BRD4HSP90AB1ESR1BCL2L1BAK1 | |
| SCHEMBL1682546 | 0.74 | ESR1 (0.39) | BRD4HSP90AB1ESR1ESR2 | |
| SCHEMBL1670808 | 0.73 | TTR (0.34) | ESR1ESR2 | |
| SCHEMBL1672899 | 0.71 | ERN1 (0.38) | BRD4BCL2L1BAK1ERN1CREBBP | |
| SCHEMBL1671583 | 0.71 | BRD4 (0.33) | BRD4ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042477-A1 | SUBSTITUTED PYRROLES AND IMIDAZOLES AS ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |