Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 9/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | ATXN2 | Q99700 | 8/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GPR183 | P32249 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.31 |
| ▸ | GLP1R | P43220 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1670770 | 0.89 | PDE5A (0.33) | — | |
| SCHEMBL11899245 | 0.89 | ENPP2 (0.44) | ENPP2DGAT2ATXN2DRD3ALDH1A1 | |
| SCHEMBL11898882 | 0.89 | ENPP2 (0.44) | ENPP2DGAT2ATXN2DRD3ALDH1A1 | |
| SCHEMBL1670653 | 0.88 | — | — | |
| SCHEMBL1671516 | 0.87 | ENPP2 (0.35) | ENPP2ATXN2 | |
| SCHEMBL1670737 | 0.86 | MGLL (0.34) | — | |
| SCHEMBL1670824 | 0.86 | GPR183 (0.32) | GPR183 | |
| SCHEMBL17888827 | 0.85 | ENPP2 (0.40) | ENPP2ATXN2 | |
| SCHEMBL11962603 | 0.83 | ENPP2 (0.38) | ENPP2DGAT2ATXN2ALDH1A1HRH2 | |
| SCHEMBL11962574 | 0.79 | ENPP2 (0.44) | ENPP2ATXN2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488504-B1 | SULFOXIDE DERIVATIVES FOR TREATING TUMORS | MERCK PATENT GMBH (DE) | 2016-07-06 | — | — | EP | disclosed |
| EP-2488504-A1 | SULFOXIDE DERIVATIVES FOR TREATING TUMORS | Merck Patent GmbH (DE) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011044978-A1 | SULFOXIDE DERIVATIVES FOR TREATING TUMORS | MERCK PATENT GMBH (DE) | 2011-04-21 | — | — | WO | disclosed |