Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | KAT7 | O95251 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.35 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709068 | 0.88 | GRM5 (0.37) | GRM5GRM1GPR119TP53HPGDS | |
| SCHEMBL16730941 | 0.85 | MAPT (0.38) | USP30KAT7KAT6AKAT5 | |
| SCHEMBL16709070 | 0.79 | CSNK1E (0.54) | — | |
| SCHEMBL16711195 | 0.78 | GRM5 (0.50) | GRM5GRM1 | |
| SCHEMBL16700187 | 0.77 | GRM5 (0.38) | GRM5TP53 | |
| SCHEMBL16709011 | 0.77 | SMN1; SMN2 (0.39) | TP53USP30 | |
| SCHEMBL30622958 | 0.77 | ABHD6 (0.43) | GRM5GPR119TP53BACE1BACE2 | |
| SCHEMBL30623015 | 0.76 | ABHD6 (0.41) | GRM5GPR119TP53BACE1BACE2 | |
| SCHEMBL16709098 | 0.75 | SCD5 (0.39) | GRM5GRM1GPR119HPGDSUSP30 | |
| SCHEMBL30623033 | 0.74 | GRM5 (0.45) | GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015073767-A1 | SUBSTITUTED 4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS CASEIN KINASE 1 D/E INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-05-21 | — | — | WO | disclosed |