Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 5/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL4476163 | 0.90 | P2RX1 (0.48) | P2RX1P2RX4P2RX7TMPRSS4MAPT | |
| Nitric Acid SCHEMBL4467533 | 0.83 | ACP1 (0.48) | P2RX1P2RX4P2RX7TMPRSS4MAPT | |
| Nitric Acid SCHEMBL4474668 | 0.82 | ATF1 (0.46) | P2RX1P2RX4P2RX7TMPRSS4MAPT | |
| Nitric Acid SCHEMBL4476359 | 0.80 | TMPRSS4 (0.46) | P2RX1TMPRSS4MAPTMEN1LMNA | |
| SCHEMBL12475189 | 0.80 | P2RX1 (0.58) | P2RX1P2RX4P2RX7TMPRSS4MAPT | |
| SCHEMBL12475193 | 0.80 | P2RX1 (0.58) | P2RX1P2RX4P2RX7TMPRSS4MAPT | |
| SCHEMBL11010708 | 0.80 | P2RX1 (0.58) | P2RX1P2RX4P2RX7TMPRSS4MAPT | |
| Nitric Acid SCHEMBL4479271 | 0.79 | ALDH1A1 (0.55) | MAPTMEN1LMNAKMT2ANPSR1 | |
| Nitric Acid SCHEMBL1664 | 0.78 | TSHR (0.50) | MAPTMEN1LMNAKMT2ANPC1 | |
| SCHEMBL28345196 | 0.78 | P2RX1 (0.57) | P2RX1P2RX4P2RX7TMPRSS4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564409-B1 | Pyrimidin derivatives and process for their preparation | NOVARTIS AG (CH) | 2000-01-19 | — | — | EP | disclosed |
| US-5521184-A | ANTITUMOR AGENTS; imatinib mesylate | CIBA-GEIGY CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0564409-A1 | Pyrimidin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-10-06 | — | — | EP | disclosed |