Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | DDX3X | O00571 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL1184113 | 0.89 | CYP1A2 (0.44) | TSHRMEN1KMT2AMAPTLMNA | |
| Nitric Acid SCHEMBL27404711 | 0.83 | TSHR (0.40) | TSHRSMN1; SMN2MEN1KMT2AMAPT | |
| Nitric Acid SCHEMBL13739225 | 0.82 | LMNA (0.36) | MEN1KMT2AMAPTLMNAHTT | |
| Nitric Acid SCHEMBL27330998 | 0.79 | LOXL2 (0.40) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL15156473 | 0.79 | TSHR (0.59) | TSHRSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL15156475 | 0.79 | TSHR (0.59) | TSHRSMN1; SMN2MEN1KMT2AMAPT | |
| Nitric Acid SCHEMBL1673 | 0.78 | P2RX1 (0.51) | MEN1KMT2AMAPTLMNANPC1 | |
| SCHEMBL9352334 | 0.78 | SMN1; SMN2 (0.61) | TSHRSMN1; SMN2MEN1KMT2AMAPT | |
| Nitric Acid SCHEMBL2283510 | 0.77 | KMT2A (0.64) | SMN1; SMN2MEN1KMT2AMAPTHTT | |
| Nitric Acid SCHEMBL1880262 | 0.77 | CYP1A2 (0.54) | SMN1; SMN2MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564409-B1 | Pyrimidin derivatives and process for their preparation | NOVARTIS AG (CH) | 2000-01-19 | — | — | EP | disclosed |
| CN-1043531-C | Pyrimidine derivatives and a process for production thereof | NOVATIS AG (CH) | 1999-06-02 | — | — | CN | disclosed |
| US-5521184-A | ANTITUMOR AGENTS; imatinib mesylate | CIBA-GEIGY CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| CN-1077713-A | Pyrimidine derivatives and preparation method thereof | CIBA GEIGY AG (CH) | 1993-10-27 | — | — | CN | disclosed |
| EP-0564409-A1 | Pyrimidin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-10-06 | — | — | EP | disclosed |