⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660061 | 0.88 | — | — | |
| Barbituric Acid SCHEMBL38707 | 0.78 | — | — | |
| Barbituric Acid SCHEMBL4560317 | 0.78 | ALDH1A1 (0.55) | — | |
| Barbituric Acid SCHEMBL9941322 | 0.78 | — | — | |
| SCHEMBL8028070 | 0.78 | — | — | |
| Barbituric Acid SCHEMBL4726594 | 0.78 | ALDH1A1 (0.44) | — | |
| Barbituric Acid SCHEMBL11379882 | 0.76 | ALDH1A1 (0.52) | — | |
| Barbituric Acid SCHEMBL5924412 | 0.76 | ALDH1A1 (0.52) | — | |
| Barbituric Acid SCHEMBL1973830 | 0.76 | ALDH1A1 (0.52) | — | |
| Barbituric Acid SCHEMBL1972516 | 0.76 | ALDH1A1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117729917-A | Combination therapy using AKR1C3 activating compounds and immune checkpoint inhibitors | 深圳艾欣达伟医药科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-114746753-A | Correlating AKR1C3 enzyme expression level through prostaglandin content and screening administration application | 深圳艾欣达伟医药科技有限公司 | 2022-07-12 | — | — | CN | claimed |
| JP-5222569-A | — | — | None | — | — | JP | disclosed |
| JP-60187695-A | — | — | None | — | — | JP | disclosed |
| CN-114728934-B | Heterocyclic derivatives, pharmaceutical compositions and their use for treating or ameliorating cancer | 托雷莫治疗股份公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-118139642-A | Compositions and methods for treating cancer | 约翰·霍普金斯大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-111743783-B | Double-paste type dental resin reinforced glass ion water-gate composition | 株式会社松风 | 2024-04-16 | — | — | CN | disclosed |
| CN-117729917-A | Combination therapy using AKR1C3 activating compounds and immune checkpoint inhibitors | 深圳艾欣达伟医药科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-117715658-A | Method for inhibiting RAS | 锐新医药公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117683049-A | Indole derivatives as RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117616031-A | RAS inhibitors for the treatment of cancer | 锐新医药公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-102250019-A | (Thio) barbituric acid compound and application thereof | UNIV SICHUAN | 2011-11-23 | — | — | CN | disclosed |
| US-20110086905-A1 | Pseudocomplementary Oligonucleotides for Targeted Gene Therapy | YALE UNIVERSITY | 2011-04-14 | — | — | US | disclosed |
| US-20070284258-A1 | Method For Silver Plating | DAIWA FINE CHEMICALS CO., LTD. (JP) | 2007-12-13 | — | — | US | disclosed |
| JP-H05222569-A | SILVER PLATING SOLUTION | SHINKO ELECTRIC IND CO LTD | 1993-08-31 | — | — | JP | disclosed |
| JP-S60187695-A | SILVER PLATING SOLUTION AND METHOD | SHINKO ELECTRIC IND CO LTD | 1985-09-25 | — | — | JP | disclosed |
| US-4375508-A | ACETHYLENIC HYDROCARBON CHAIN | EASTMAN KODAK COMPANY (US) | 1983-03-01 | — | — | US | disclosed |
| US-4283488-A | SILVER HALIDE EMULSIONS | EASTMAN KODAK COMPANY (US) | 1981-08-11 | — | — | US | disclosed |
| US-4108667-A | Photographic compositions and elements containing benzo[a]quinolizinium methine dyes | EASTMAN KODAK COMPANY (US) | 1978-08-22 | — | — | US | disclosed |
| US-4003750-A | METHINE DYES | EASTMAN KODAK COMPANY (US) | 1977-01-18 | — | — | US | disclosed |