Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735377 | 0.91 | MAPT (0.50) | GAASMN1; SMN2CYP1A2ALDH1A1HTT | |
| SCHEMBL30401975 | 0.73 | MAPT (0.63) | SMN1; SMN2CYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL24399727 | 0.73 | MAPT (0.63) | SMN1; SMN2CYP1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL12501061 | 0.72 | SMN1; SMN2 (1.00) | GAASMN1; SMN2CYP1A2ALDH1A1HTT | |
| SCHEMBL16735267 | 0.71 | RAF1 (0.55) | GAASMN1; SMN2CYP1A2ALDH1A1HTT | |
| SCHEMBL23455423 | 0.69 | AKR1C3 (0.60) | GAASMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL30073952 | 0.69 | AKR1C3 (0.60) | GAASMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL2443393 | 0.68 | CXCR2 (0.49) | SMN1; SMN2ALDH1A1HTTNPC1MEN1 | |
| SCHEMBL2443395 | 0.68 | PIM1 (0.43) | GAASMN1; SMN2ALDH1A1HTTRAB9A | |
| SCHEMBL12478150 | 0.67 | RAB9A (1.00) | GAASMN1; SMN2ALDH1A1HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9388165-B2 | Isoquinoline-5-carboxamide derivative having inhibitory activity for protein kinase | HANMI PHARM. CO., LTD. (KR) | 2016-07-12 | — | — | US | disclosed |
| US-20150191450-A1 | ISOQUINOLINE-5-CARBOXAMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | HANMI PHARM. CO., LTD. (KR) | 2015-07-09 | — | — | US | disclosed |
| EP-2876107-A1 | ISOQUINOLINE-5-CARBOXAMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | Hanmi Pharm. Co., Ltd. (KR) | 2015-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191450-A1 | ISOQUINOLINE-5-CARBOXAMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | CSNK1A1, MAP3K5, MAP4K2 | GAA 2471/4885SMN1; SMN2 2745/4885CYP1A2 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.