Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446777 | 0.78 | NPC1 (0.39) | PIM1BRD4GAANPC1RAB9A | |
| SCHEMBL4074720 | 0.72 | DEGS1 (0.55) | GAANPC1RAB9AMITFTP53 | |
| Hydrochloric Acid SCHEMBL38658381 | 0.70 | DEGS1 (0.54) | GAANPC1RAB9AMITFTP53 | |
| SCHEMBL2443393 | 0.68 | CXCR2 (0.49) | NPC1IDO1TDO2DEGS1SMN1; SMN2 | |
| SCHEMBL16735362 | 0.68 | GAA (0.56) | GAANPC1RAB9AIDO1TDO2 | |
| SCHEMBL16245710 | 0.67 | GAA (0.56) | GAANPC1RAB9AMITFTP53 | |
| SCHEMBL23455423 | 0.67 | AKR1C3 (0.60) | GAANPC1RAB9AMITFAKR1C3 | |
| SCHEMBL30073952 | 0.67 | AKR1C3 (0.60) | GAANPC1RAB9AMITFAKR1C3 | |
| SCHEMBL287134 | 0.66 | P4HTM (0.60) | ALDH1A1KDM4EHPGDMAPTTDP1 | |
| SCHEMBL30490235 | 0.66 | NNMT (0.59) | DEGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627652-B1 | PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAE WOONG PHARMA (KR) | 2015-12-16 | — | — | EP | disclosed |
| EP-2627652-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | Daewoong Pharmaceutical Co., Ltd (KR) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012050380-A2 | NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2012-04-19 | — | — | WO | disclosed |
| US-8026235-B1 | Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2011-09-27 | — | — | US | disclosed |