Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9931015 | 0.89 | ALDH1A1 (0.71) | CCR2ALDH1A1BRAFTP53MEN1 | |
| SCHEMBL9931094 | 0.86 | CCR2 (0.74) | CCR2ALDH1A1BRAFTP53 | |
| SCHEMBL9930939 | 0.83 | CCR2 (0.61) | CCR2BRAFMEN1LMNAMAPT | |
| SCHEMBL19415716 | 0.82 | CCR2 (0.64) | CCR2ALDH1A1BRAFTP53MEN1 | |
| SCHEMBL9931122 | 0.80 | CCR2 (0.67) | CCR2BRAFTP53MEN1LMNA | |
| SCHEMBL9931411 | 0.80 | CCR2 (0.58) | CCR2BRAFMEN1LMNAMAPT | |
| SCHEMBL16735479 | 0.80 | CCR2 (0.71) | CCR2BRAFMEN1LMNAKMT2A | |
| SCHEMBL9931235 | 0.80 | CCR2 (0.68) | CCR2BRAFMEN1LMNAMAPT | |
| SCHEMBL9930712 | 0.80 | CCR2 (0.73) | CCR2BRAFMEN1LMNAMAPT | |
| SCHEMBL16735476 | 0.80 | SMN1; SMN2 (0.56) | CCR2TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2955173-B1 | 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2017-10-04 | — | — | EP | claimed |
| EP-2651901-B1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2015-05-27 | — | — | EP | claimed |
| EP-2955173-B1 | 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2017-10-04 | — | — | EP | disclosed |
| EP-2955173-A1 | NOVEL 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-12-16 | — | — | EP | disclosed |