Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735638 | 0.88 | MAOB (0.47) | HSP90AA1HSP90AB1MEN1KMT2AL3MBTL1 | |
| SCHEMBL16735654 | 0.88 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1HTTCYP1A2CYP2C19 | |
| SCHEMBL16735574 | 0.85 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1HTTCYP2C19ALDH1A1 | |
| SCHEMBL16735599 | 0.83 | PDK1 (0.51) | HSP90AA1L3MBTL1PDK2PDK1PDK3 | |
| SCHEMBL16735621 | 0.78 | TP53 (0.43) | HSP90AA1HTTCYP2C19ALDH1A1MEN1 | |
| SCHEMBL2143825 | 0.78 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1 | |
| SCHEMBL16735657 | 0.77 | PDK1 (0.49) | HSP90AA1ALDH1A1PDK2PDK1PDK3 | |
| SCHEMBL16735648 | 0.76 | HSP90AA1 (0.43) | HSP90AA1HTTALDH1A1MEN1KMT2A | |
| SCHEMBL16735652 | 0.75 | HSP90AA1 (0.46) | HSP90AA1PDK1RAB9ANPC1 | |
| SCHEMBL16735575 | 0.74 | HSP90AA1 (0.58) | HSP90AA1ALDH1A1MEN1KMT2APDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |