Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 19/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16738387 | 0.83 | GPBAR1 (0.60) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL16738479 | 0.83 | GPBAR1 (0.58) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL2334094 | 0.79 | GPBAR1 (1.00) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL2330300 | 0.79 | GPBAR1 (0.79) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL28814950 | 0.78 | GPBAR1 (0.52) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL15060484 | 0.76 | GPBAR1 (0.68) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL15933796 | 0.76 | GPBAR1 (0.70) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL2331886 | 0.76 | GPBAR1 (0.93) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL2215165 | 0.75 | GPBAR1 (0.75) | GPBAR1CYP3A4CYP2C9 | |
| SCHEMBL2216480 | 0.74 | GPBAR1 (1.00) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | GLP1R, GPR119, TRHR | GPBAR1 46/4885CYP3A4 3157/4885CYP2C9 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.