Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16750384 | 1.00 | GPBAR1 (0.57) | GPBAR1 | |
| SCHEMBL16738638 | 0.90 | GPBAR1 (0.59) | GPBAR1 | |
| SCHEMBL16738617 | 0.83 | GPBAR1 (0.57) | GPBAR1 | |
| SCHEMBL16750385 | 0.83 | GPBAR1 (0.57) | GPBAR1 | |
| SCHEMBL16750474 | 0.83 | GPBAR1 (0.59) | GPBAR1 | |
| SCHEMBL16750386 | 0.82 | GPBAR1 (0.60) | GPBAR1 | |
| SCHEMBL16738602 | 0.82 | GPBAR1 (0.60) | GPBAR1 | |
| SCHEMBL16738506 | 0.77 | GPBAR1 (0.64) | GPBAR1 | |
| SCHEMBL15079328 | 0.76 | GPBAR1 (0.65) | GPBAR1 | |
| SCHEMBL16738395 | 0.75 | GPBAR1 (0.59) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | ARDELYX INC (US) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148311-A1 | NON-SYSTEMIC TGR5 AGONISTS | GLP1R, GPR119, TRHR | GPBAR1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.