Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16747924 | 0.91 | BMI1 (0.48) | BMI1BRAFKCNH2SCN5ASCN9A | |
| SCHEMBL16739738 | 0.81 | CYP1A2 (0.47) | BMI1CYP1A2CYP2C19ALDH1A1MEN1 | |
| SCHEMBL16739766 | 0.70 | CYP1A2 (0.49) | CYP1A2CYP2C19ALDH1A1MEN1KMT2A | |
| SCHEMBL16747833 | 0.68 | PKM (0.48) | BMI1ALDH1A1MEN1KMT2ACLK4 | |
| SCHEMBL16740059 | 0.67 | PTGDR2 (0.42) | BRAFKCNH2SCN5ASCN9A | |
| SCHEMBL16739788 | 0.66 | SRC (0.48) | CYP1A2CYP2C19ALDH1A1MEN1KMT2A | |
| SCHEMBL16739729 | 0.66 | KCNH2 (0.43) | BMI1BRAFMAPTBRD4KCNH2 | |
| SCHEMBL16740224 | 0.66 | NR3C1 (0.47) | CYP2C19CYP3A4KCNH2SCN5ASCN9A | |
| SCHEMBL16740063 | 0.65 | BMI1 (0.46) | BMI1BRAFKCNH2SCN5ASCN9A | |
| SCHEMBL16740320 | 0.65 | BRAF (0.46) | BMI1MEN1KMT2ABRAFKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071553-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC Therapeutics, Inc. (US) | 2016-09-28 | — | — | EP | claimed |
| WO-2015076800-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. (US) | 2015-05-28 | — | — | WO | claimed |