Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F11 | P03951 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523141 | 0.86 | KMT2A (0.47) | HIF1AKDM4EMEN1MAPTKMT2A | |
| SCHEMBL15141616 | 0.82 | CA1 (0.47) | HIF1ALPLLIPGGAA | |
| SCHEMBL58123 | 0.81 | KDR (0.51) | HIF1AMEN1KMT2ANTRK1 | |
| SCHEMBL12107159 | 0.80 | HIF1A (0.44) | HIF1ALPLLIPGGAA | |
| SCHEMBL28341813 | 0.75 | AAK1 (0.40) | HIF1AKDM4EKMT2AF2F11 | |
| SCHEMBL516237 | 0.75 | F2 (0.40) | HIF1AF2F11PRSS1PRSS2 | |
| SCHEMBL20562627 | 0.74 | ROCK1 (0.42) | HIF1AMEN1KMT2AF2F11 | |
| SCHEMBL23798209 | 0.74 | F2 (0.44) | HIF1AKDM4EF2F11PRSS1 | |
| SCHEMBL29764068 | 0.73 | DGAT1 (0.41) | HIF1AKDM4EMEN1MAPTKMT2A | |
| SCHEMBL13480590 | 0.73 | GAA (0.55) | ABL1KDM4EMEN1KMT2ANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3109249-A1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | YM BioSciences Australia Pty Ltd (AU) | 2016-12-28 | — | — | EP | disclosed |
| US-9499560-B2 | N-containing heterocyclic compounds | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2016-11-22 | — | — | US | disclosed |
| EP-2215094-B1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2016-01-27 | — | — | EP | disclosed |
| US-8765755-B2 | N-containing heterocyclic compounds | YM BIOSCIENCES AUSTRALIA PTY LTD. (AU) | 2014-07-01 | — | — | US | disclosed |
| US-20130090336-A1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2013-04-11 | — | — | US | disclosed |
| US-8354408-B2 | N-containing heterocyclic compounds | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2013-01-15 | — | — | US | disclosed |
| US-20110092499-A1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | YM BIOSCIENCES AUSTRALIA PTY LTD (AU) | 2011-04-21 | — | — | US | disclosed |
| EP-2215094-A1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | YM BioSciences Australia Pty Ltd (AU) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009062258-A1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | CYTOPIA RESEARCH PTY LTD (AU) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090336-A1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | JAK2, JAK3, JAK1 | HIF1A 1555/4885ABL1 15/4885PYGL 817/4885 |
| US-20110092499-A1 | N-CONTAINING HETEROCYCLIC COMPOUNDS | JAK2, JAK3, JAK1 | HIF1A 1555/4885ABL1 15/4885PYGL 817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.