Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21198240 | 0.86 | HIF1A (0.42) | KDM4EMAPTALDH1A1LMNAHIF1A | |
| SCHEMBL1674041 | 0.86 | HIF1A (0.40) | KMT2AKDM4EMEN1MAPTHIF1A | |
| SCHEMBL21202188 | 0.85 | HTT (0.59) | KMT2AMEN1MAPTALDH1A1HIF1A | |
| SCHEMBL12107159 | 0.84 | HIF1A (0.44) | HIF1AGAA | |
| SCHEMBL16907820 | 0.84 | HTT (0.52) | ALDH1A1HIF1AHTTGAAPKM | |
| SCHEMBL2073317 | 0.84 | HIF1A (0.46) | ALDH1A1LMNAHIF1AHTTGAA | |
| SCHEMBL1743265 | 0.84 | HSD17B1 (0.47) | KMT2AMEN1MAPTALDH1A1HIF1A | |
| SCHEMBL18250078 | 0.83 | LPAR1 (0.43) | KMT2AKDM4EMAPTALDH1A1LMNA | |
| SCHEMBL15141616 | 0.83 | CA1 (0.47) | LMNAHIF1AGAAPKM | |
| SCHEMBL18216864 | 0.83 | HIF1A (0.48) | KMT2AMEN1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3740493-B1 | INHIBTEURS DE L'INDOLEAMINE 2,3-DIOXYGÉNASE ET/OU DU TRYPTOPHANE DIOXYGÉNASE | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-12-01 | — | — | EP | disclosed |
| US-20200405696-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | IDORSIA PHARMACEUTICALS LTD (CH) | 2020-12-31 | — | — | US | disclosed |
| EP-3740493-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | Idorsia Pharmaceuticals Ltd (CH) | 2020-11-25 | — | — | EP | disclosed |
| CN-111601810-A | Inhibitors of indoleamine 2, 3-dioxygenase and/or tryptophan 2, 3-dioxygenase | 爱杜西亚药品有限公司 | 2020-08-28 | — | — | CN | disclosed |
| EP-1904478-B1 | ACID ADDITION SALTS OF N-ETHYL-N'-[2-METHOXY-4-(5-METHYL-4-{[(1S)-1-PYRIDIN-3-YLBUTYL]AMINO}PYRIMIDIN- 2-YL)PHENYL]UREA AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2013-07-24 | — | — | EP | disclosed |
| US-20090281119-A1 | ACID ADDITION SALTS OF N-ETHYI-N'-[2-METHOXY-4-(5-METHYI-4-PRYIMIDIN-2-YL)PHENYL]UREA AND USES THEREOF | CYTOPIA RESEARCH PTY LTD. (AU) | 2009-11-12 | — | — | US | disclosed |
| EP-1904478-A1 | ACID ADDITION SALTS OF N-ETHYL-N'-[2-METHOXY-4-(5-METHYL-4-{[(1S)-1-PYRIDIN-3-YLBUTYL]AMINO}PYRIMIDIN- 2-YL)PHENYL]UREA AND USES THEREOF | Cytopia Research Pty Ltd (AU) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006133498-A1 | ACID ADDITION SALTS OF N-ETHYI-N'-[2-METHOXY-4-(5-METHYI-4-{[(1S)-1-PYRIDIN-3-YLBUTYI]AMINO}PYRIMIDIN- 2-YL)PHENYL]UREA AND USES THEREOF | CYTOPIA RESEARCH PTY LTD (AU) | 2006-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281119-A1 | ACID ADDITION SALTS OF N-ETHYI-N'-[2-METHOXY-4-(5-METHYI-4-PRYIMIDIN-2-YL)PHENYL]UREA AND USES THEREOF | PAH, CCNY, UMPS | KMT2A 694/4885KDM4E 194/4885MEN1 615/4885 |
| US-20200405696-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE | IDO2, TDO2, IDO1 | KMT2A 1208/4885KDM4E 1391/4885MEN1 2966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.