Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18589423 | 0.84 | CHIT1 (0.36) | — | |
| SCHEMBL18607672 | 0.84 | CHIT1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL18577079 | 0.83 | CHIT1 (0.36) | — | |
| SCHEMBL7915444 | 0.81 | BCHE (0.48) | CTSC | |
| SCHEMBL7915130 | 0.81 | BCHE (0.48) | CTSC | |
| SCHEMBL7915133 | 0.81 | BCHE (0.48) | CTSC | |
| SCHEMBL19226396 | 0.81 | POLB (0.45) | POLBMEN1KMT2A | |
| SCHEMBL27540551 | 0.80 | POLB (0.39) | POLBMEN1KMT2A | |
| SCHEMBL23477963 | 0.77 | POLB (0.47) | POLBMEN1KMT2A | |
| SCHEMBL14360008 | 0.77 | POLB (0.47) | POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071570-A1 | 2,6-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | Pfizer Inc. (US) | 2016-09-28 | — | — | EP | disclosed |
| WO-2015075598-A1 | 2,6-SUBSTITUTED PURINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | PFIZER INC. (US) | 2015-05-28 | — | — | WO | disclosed |