Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15214836 | 0.90 | SMN1; SMN2 (0.48) | GAANPSR1SMN1; SMN2KMT2AHTT | |
| SCHEMBL12125162 | 0.89 | FAAH (0.45) | GAANPSR1SMN1; SMN2KMT2AHTT | |
| SCHEMBL12125161 | 0.86 | FAAH (0.43) | GAANPSR1SMN1; SMN2KMT2AHTT | |
| SCHEMBL25500845 | 0.84 | KMT2A (0.61) | GAASMN1; SMN2KMT2AHTTTDP1 | |
| SCHEMBL12125160 | 0.82 | MAPT (0.44) | GAANPSR1KMT2AHTTABL1 | |
| SCHEMBL9973048 | 0.81 | MAPT (0.41) | GAANPSR1SMN1; SMN2KMT2AHTT | |
| SCHEMBL15214806 | 0.81 | THRB (0.50) | GAANPSR1SMN1; SMN2KMT2AHTT | |
| SCHEMBL13135270 | 0.79 | KMT2A (0.68) | GAASMN1; SMN2KMT2AHTTTDP1 | |
| SCHEMBL13135348 | 0.79 | KMT2A (0.68) | GAASMN1; SMN2KMT2AHTTTDP1 | |
| SCHEMBL11411338 | 0.78 | HTT (0.54) | SMN1; SMN2KMT2AHTTTDP1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144324-A1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2015077147-A1 | METHOD OF PREPARING FUSED RING INDENO COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
| WO-2015077141-A1 | FUSED RING INDENO COMPOUNDS FOR PREPARATION OF PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | disclosed |