Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.49 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17656088 | 0.94 | HDAC3 (0.56) | NPC1RAB9AKMT2AHDAC3HDAC11 | |
| SCHEMBL13536568 | 0.91 | RAB9A (0.64) | NPC1RAB9AKMT2AHDAC3HDAC11 | |
| SCHEMBL15214833 | 0.89 | HDAC8 (0.62) | NPC1RAB9AKMT2AHDAC3HDAC11 | |
| SCHEMBL16021444 | 0.86 | HDAC3 (0.62) | NPC1RAB9AHDAC3HDAC11HDAC8 | |
| SCHEMBL16704905 | 0.86 | HDAC3 (0.62) | NPC1RAB9AHDAC3HDAC11HDAC8 | |
| SCHEMBL15214804 | 0.84 | HDAC8 (0.69) | NPC1RAB9AKMT2AHDAC3HDAC11 | |
| SCHEMBL15214807 | 0.83 | HDAC8 (0.64) | NPC1RAB9AKMT2AHDAC3HDAC11 | |
| SCHEMBL12125151 | 0.82 | ALDH1A1 (0.51) | NPC1RAB9AKMT2AHDAC3HDAC11 | |
| SCHEMBL9973043 | 0.82 | NPC1 (0.46) | NPC1RAB9AKMT2AHDAC3HDAC11 | |
| SCHEMBL16744189 | 0.82 | HDAC3 (0.51) | NPC1RAB9AKMT2AHDAC3HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015077147-A1 | METHOD OF PREPARING FUSED RING INDENO COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
| WO-2015077141-A1 | FUSED RING INDENO COMPOUNDS FOR PREPARATION OF PHOTOCHROMIC COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2015-05-28 | — | — | WO | disclosed |