Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Stavudine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | TK1 | P04183 | 3/20 | 0.43 |
| ▸ | TYMP | P19971 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477 | 0.87 | TK1 (0.43) | ALDH1A1LMNAALBPOLBADRA1A | |
| SCHEMBL28129115 | 0.87 | TK1 (0.43) | ALDH1A1LMNAALBPOLBADRA1A | |
| Hydrochloric Acid SCHEMBL28100272 | 0.85 | TK1 (0.42) | ALDH1A1LMNAALBPOLBADRA1A | |
| Phosphoric Acid SCHEMBL9392093 | 0.82 | TYMP (0.43) | ALDH1A1LMNAALBPOLBADRA1A | |
| Phosphoric Acid SCHEMBL3092301 | 0.82 | TYMP (0.43) | ALDH1A1LMNAALBPOLBADRA1A | |
| SCHEMBL28839372 | 0.82 | TK1 (0.40) | ALDH1A1LMNAALBPOLBADRA1A | |
| Stavudine SCHEMBL3234890 | 0.82 | ALDH1A1 (1.00) | ALDH1A1LMNAALBPOLBADRA1A | |
| Stavudine SCHEMBL8540086 | 0.82 | ALDH1A1 (1.00) | ALDH1A1LMNAALBPOLBADRA1A | |
| Stavudine SCHEMBL9999805 | 0.82 | ALDH1A1 (1.00) | ALDH1A1LMNAALBPOLBADRA1A | |
| Stavudine SCHEMBL18474938 | 0.82 | ALDH1A1 (1.00) | ALDH1A1LMNAALBPOLBADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085377-A1 | METHODS OF TREATING VIRAL INFECTIONS | Chimerix, Inc. (US) | 2016-10-26 | — | — | EP | disclosed |
| US-8609609-B2 | Peptides and methods of use as therapeutics and screening agents | NORTH CAROLINA STATE UNIVERSITY (US) | 2013-12-17 | — | — | US | disclosed |
| EP-2240604-B1 | PEPTIDES AND METHODS OF USE AS THERAPEUTICS AND SCREENING AGENTS | UNIV NORTH CAROLINA STATE (US) | 2012-07-25 | — | — | EP | disclosed |
| US-20110098215-A1 | PEPTIDES AND METHODS OF USE AS THERAPEUTICS AND SCREENING AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-28 | — | — | US | disclosed |
| EP-2240604-A2 | PEPTIDES AND METHODS OF USE AS THERAPEUTICS AND SCREENING AGENTS | North Carolina State University (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009091586-A2 | PEPTIDES AND METHODS OF USE AS THERAPEUTICS AND SCREENING AGENTS | NORTH CAROLINA STATE UNIVERSITY (US) | 2009-07-23 | — | — | WO | disclosed |