SCHEMBL16746512

SCHEMBL16746512

CCS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1nc2cc(C)ccc2o1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RY14 Q15391 1/20 0.46
KDM4E B2RXH2 5/20 0.44
HPGD P15428 4/20 0.44
RAB9A P51151 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
NPC1 O15118 3/20 0.44
ALDH1A1 P00352 3/20 0.44
HSD17B10 Q99714 2/20 0.44
TP53 P04637 1/20 0.44
MAPT P10636 2/20 0.44
AGPAT2 O15120 5/20 0.42
POLB P06746 2/20 0.42
CASP3 P42574 2/20 0.42
SENP8 Q96LD8 2/20 0.42
SENP7 Q9BQF6 2/20 0.42
SENP6 Q9GZR1 2/20 0.42
UTRN P46939 3/20 0.42
DDR1 Q08345 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15616841 0.93 AGPAT2 (0.47) RAB9ANPC1MAPTAGPAT2UTRN
SCHEMBL9951989 0.84 UTRN (0.49) KDM4EHPGDALDH1A1AGPAT2POLB
SCHEMBL1023895 0.81 AGPAT2 (0.44) MAPTAGPAT2UTRNDDR1MEN1
SCHEMBL15426362 0.81 KDM4E (0.55) KDM4EHPGDRAB9ASMN1; SMN2NPC1
SCHEMBL16746513 0.79 KDM4E (0.45) P2RY14KDM4EHPGDRAB9ASMN1; SMN2
SCHEMBL4544493 0.78 KDM4E (0.47) KDM4EHPGDRAB9ASMN1; SMN2NPC1
SCHEMBL29814188 0.78 AGPAT2 (0.41) MAPTAGPAT2UTRNDDR1MEN1
SCHEMBL20633528 0.78 AGPAT2 (0.41) MAPTAGPAT2UTRNDDR1MEN1
SCHEMBL17733125 0.78 UTRN (0.42) P2RY14RAB9ANPC1MAPTAGPAT2
SCHEMBL22190405 0.77 AGPAT2 (0.40) SMN1; SMN2ALDH1A1MAPTAGPAT2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150148308-A1 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS SFXN1, OSR1, PIR P2RY14 1081/4885KDM4E 1144/4885HPGD 4672/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.