Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20178601 | 0.81 | KAT6A (0.54) | HPGDSCN9AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7973340 | 0.81 | PLK1 (0.61) | PLK1HPGDSCN9ALMNAALDH1A1 | |
| SCHEMBL7987067 | 0.81 | PLK1 (0.61) | PLK1HPGDLMNAALDH1A1TDP1 | |
| SCHEMBL15018194 | 0.79 | HTR7 (0.49) | SCN9AALDH1A1SMN1; SMN2GAAHDAC6 | |
| SCHEMBL30755385 | 0.79 | HDAC1 (0.52) | SCN9ALMNAALDH1A1SMN1; SMN2GAA | |
| SCHEMBL7973254 | 0.77 | PLK1 (0.56) | PLK1HPGDLMNAALDH1A1TDP1 | |
| SCHEMBL19333622 | 0.77 | LMNA (0.50) | HPGDSCN9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6918025 | 0.76 | PLK1 (0.70) | PLK1ALDH1A1TDP1TAS1R3TAS1R1 | |
| SCHEMBL14416780 | 0.75 | PLK1 (0.54) | PLK1HPGDSCN9ALMNAALDH1A1 | |
| SCHEMBL10766721 | 0.74 | ATM (0.60) | LMNAALDH1A1TDP1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2876105-A1 | 1-(CYCLOALKYL-CARBONYL)PROLINE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2015-05-27 | — | — | EP | disclosed |