Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.45 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400290 | 0.82 | NTRK1 (0.46) | JAK2NTRK1TYK2IRAK4LMNA | |
| SCHEMBL403308 | 0.77 | JAK2 (0.44) | JAK2NTRK1IRAK4LMNA | |
| SCHEMBL406387 | 0.77 | LMNA (0.44) | JAK2NTRK1TYK2IRAK4KDM4E | |
| SCHEMBL406662 | 0.77 | NTRK1 (0.45) | JAK2NTRK1IRAK4LMNA | |
| SCHEMBL405635 | 0.76 | NTRK1 (0.56) | JAK2NTRK1TYK2 | |
| SCHEMBL402374 | 0.76 | TGFBR1 (0.49) | JAK2NTRK1TYK2IRAK4LMNA | |
| SCHEMBL15428578 | 0.76 | NTRK1 (0.45) | JAK2NTRK1TYK2EPHB3LMNA | |
| SCHEMBL402213 | 0.75 | NTRK1 (0.43) | JAK2NTRK1IRAK4KDM4EHSD17B10 | |
| SCHEMBL406643 | 0.75 | NTRK1 (0.56) | JAK2NTRK1 | |
| SCHEMBL401376 | 0.75 | JAK2 (0.42) | JAK2NTRK1TYK2IRAK4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348860-B1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH INC (US) | 2015-05-27 | — | — | EP | disclosed |