Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | APAF1 | O14727 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | ECE1 | P42892 | 9/20 | 0.64 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.63 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.63 |
| ▸ | ITGAL | P20701 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15592745 | 1.00 | ACE (0.70) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL19737124 | 1.00 | ACE (0.70) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL1263833 | 0.92 | KDM4E (0.72) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL1263822 | 0.92 | KDM4E (0.72) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL8254531 | 0.91 | ACE (0.68) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL5870457 | 0.91 | ACE (0.68) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL23423098 | 0.90 | KDM4E (0.61) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL7201046 | 0.90 | ACE (0.67) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL22800779 | 0.89 | KDM4E (0.60) | ACEKDM4EMAPTAPAF1POLB | |
| SCHEMBL13233530 | 0.89 | KDM4E (0.60) | ACEKDM4EMAPTAPAF1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376418-B2 | Substituted pyridine spleen tyrosine kinase (SYK) inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150148327-A1 | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK CANADA INC. (CA) | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148327-A1 | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS | SYK, BTK, LYN | ACE 2567/4885KDM4E 614/4885MAPT 3230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.