Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 10/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL6982256 | 0.89 | TSHR (0.36) | TSHRALDH1A1TP53HIF1ACYP3A4 | |
| SCHEMBL65009 | 0.84 | ALDH1A1 (0.46) | TSHRTDP1ALDH1A1TP53HIF1A | |
| SCHEMBL27778816 | 0.84 | ALDH1A1 (0.46) | TSHRTDP1ALDH1A1TP53HIF1A | |
| Lactic Acid SCHEMBL28118798 | 0.84 | TP53 (0.41) | TSHRALDH1A1TP53 | |
| Propylene Glycol SCHEMBL5797912 | 0.83 | TSHR (0.44) | TSHRTDP1ALDH1A1TP53HIF1A | |
| SCHEMBL7567178 | 0.82 | ALDH1A1 (0.44) | TSHRTDP1ALDH1A1TP53HIF1A | |
| SCHEMBL20954076 | 0.82 | ALDH1A1 (0.44) | TSHRTDP1ALDH1A1TP53HIF1A | |
| SCHEMBL20954079 | 0.82 | ALDH1A1 (0.44) | TSHRTDP1ALDH1A1TP53HIF1A | |
| SCHEMBL21616688 | 0.82 | ALDH1A1 (0.44) | TSHRTDP1ALDH1A1TP53HIF1A | |
| SCHEMBL9775693 | 0.82 | ALDH1A1 (0.44) | TSHRTDP1ALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2878613-B1 | Stabilizer for thiol-ene compositions | ALLNEX Belgium SA (BE) | 2016-09-14 | — | — | EP | disclosed |
| EP-2878613-A1 | Stabilizer for thiol-ene compositions | Allnex Belgium, S.A. (BE) | 2015-06-03 | — | — | EP | disclosed |