Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.89 |
| ▸ | MAPT | P10636 | 3/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.89 |
| ▸ | LMNA | P02545 | 2/20 | 0.89 |
| ▸ | TSHR | P16473 | 2/20 | 0.89 |
| ▸ | BLM | P54132 | 2/20 | 0.89 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.89 |
| ▸ | MEN1 | O00255 | 2/20 | 0.89 |
| ▸ | MPO | P05164 | 1/20 | 0.89 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | APAF1 | O14727 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL424582 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27137714 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL7056081 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL424583 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7056086 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6046200 | 0.95 | KMT2A (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL4287329 | 0.95 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6033338 | 0.95 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7103661 | 0.95 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL23141133 | 0.94 | KMT2A (1.00) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4340592-A | OLICOPEPTIDES FOR DIETARY PURPOSES | ADIBI SIAMAK A | 1982-07-20 | — | — | US | claimed |
| US-9458197-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150110755-A1 | ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME | NULASTIN, INC. | 2015-04-23 | — | — | US | disclosed |
| US-20150004184-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2015-01-01 | — | — | US | disclosed |
| US-8871707-B2 | Elastin producing fibroblast formulations and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-10-28 | — | — | US | disclosed |
| US-8828927-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130295122-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2013-11-07 | — | — | US | disclosed |
| US-8461113-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110081322-A1 | ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME | NULASTIN, INC. | 2011-04-07 | — | — | US | disclosed |
| US-20090281044-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2009-11-12 | — | — | US | disclosed |