Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.89 |
| ▸ | MAPT | P10636 | 3/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.89 |
| ▸ | LMNA | P02545 | 2/20 | 0.89 |
| ▸ | TSHR | P16473 | 2/20 | 0.89 |
| ▸ | BLM | P54132 | 2/20 | 0.89 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.89 |
| ▸ | MEN1 | O00255 | 2/20 | 0.89 |
| ▸ | MPO | P05164 | 1/20 | 0.89 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | APAF1 | O14727 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL1675340 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27137714 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL7056081 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL424583 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7056086 | 1.00 | KDM4E (0.89) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6046200 | 0.95 | KMT2A (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL4287329 | 0.95 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6033338 | 0.95 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL7103661 | 0.95 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL23141133 | 0.94 | KMT2A (1.00) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106478771-A | A kind of synthetic method of amino acid neural tetrapeptide | 李世军 | 2017-03-08 | — | — | CN | claimed |
| CN-106279354-A | A kind of synthetic method of amino acid neural dipeptides | 温州医科大学 | 2017-01-04 | — | — | CN | claimed |
| CN-116507349-A | Probiotic bacillus compositions and methods of use | 生物编辑有限责任公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-113683661-B | Dual-response dipeptide supramolecular polymer and preparation method and application thereof | 济宁医学院 | 2022-03-11 | — | — | CN | disclosed |
| CN-113683661-B | Dual-response dipeptide supramolecular polymer and preparation method and application thereof | 济宁医学院 | 2022-03-11 | — | — | CN | disclosed |
| CN-113683661-A | Dual-response dipeptide supramolecular polymer and preparation method and application thereof | 济宁医学院 | 2021-11-23 | — | — | CN | disclosed |
| CN-113683661-A | Dual-response dipeptide supramolecular polymer and preparation method and application thereof | 济宁医学院 | 2021-11-23 | — | — | CN | disclosed |
| US-10456736-B2 | Method and apparatus for purification and treatment of air | PALOZA LLC (US) | 2019-10-29 | — | — | US | disclosed |
| EP-3277083-A1 | ORGAN PRESERVATION COMPOSITION | TX Innovations B.V. (NL) | 2018-02-07 | — | — | EP | disclosed |
| CN-107156652-A | A kind of preparation method and its usage of multi-functional edible material | 江苏大学 | 2017-09-15 | — | — | CN | disclosed |
| US-20170106333-A1 | Method and Apparatus for Purification and Treatment of Air | PALOZA LLC | 2017-04-20 | — | — | US | disclosed |
| CN-1190097-A | Propiophenone derivatives and process for preparing the same | TANABE SEIYAKU CO (JP) | 1998-08-12 | — | — | CN | disclosed |
| EP-0726936-A1 | LIQUID DETERGENTS WITH ORTHO-SUBSTITUTED PHENYLBORONIC ACIDS FOR INHIBITION OF PROTEOLYTIC ENZYME | THE PROCTER & GAMBLE COMPANY (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5438118-A | Peptide mimics having constrained peptide backbone | SMITHKLINE BEECHMAN CORP. (US) | 1995-08-01 | — | — | US | disclosed |
| US-5436127-A | Polypeptides for antibodies | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| WO-1995012655-A1 | LIQUID DETERGENTS WITH ORTHO-SUBSTITUTED PHENYLBORONIC ACIDS FOR INHIBITION OF PROTEOLYTIC ENZYME | THE PROCTER & GAMBLE COMPANY (US) | 1995-05-11 | — | — | WO | disclosed |
| US-5194600-A | Genes which participate in β-glucan assembly and use thereof | ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING (CA) | 1993-03-16 | — | — | US | disclosed |
| US-5061693-A | Hexapeptides, anticoagulants | MERCK & CO., INC. (US) | 1991-10-29 | — | — | US | disclosed |
| US-4798778-A | ETHYLENE POLYMER WITH CARBOXY ACID DERIVATIVE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-01-17 | — | — | US | disclosed |
| US-4393201-A | DEOXYRIBONUCLEIC ACID | THE WISTAR INSTITUTE (US) | 1983-07-12 | — | — | US | disclosed |