Tryptophan

Tryptophan

SCHEMBL424583

NCC(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 known ✓ P0DMS8 1/20 0.61
KDM4E B2RXH2 3/20 0.89
MAPT P10636 3/20 0.89
KMT2A Q03164 3/20 0.89
LMNA P02545 2/20 0.89
TSHR P16473 2/20 0.89
BLM P54132 2/20 0.89
PMP22 Q01453 2/20 0.89
MEN1 O00255 2/20 0.89
MPO P05164 1/20 0.89
HIF1A Q16665 1/20 0.89
SMN1; SMN2 Q16637 1/20 0.63
APAF1 O14727 1/20 0.62
POLB P06746 1/20 0.62
RECQL P46063 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
HTR2A P28223 3/20 0.61
HTR1A P08908 2/20 0.61
HTR2C P28335 2/20 0.61
SLC6A4 P31645 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL1675340 1.00 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL424582 1.00 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL27137714 1.00 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL7056081 1.00 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL7056086 1.00 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL6046200 0.95 KMT2A (0.80) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL4287329 0.95 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL6033338 0.95 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL7103661 0.95 KDM4E (0.80) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL23141133 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117599013-A Nanometer composition, preparation method and application thereof 赣州和美药业股份有限公司 2024-02-27 CN claimed
US-20230258556-A1 Nanozeolites and their Analytical Use as Chemosensors in Biorelevant Media Karlsruher Institut für Technologie (DE) 2023-08-17 US claimed
CN-116444685-A Efficient controllable RNA delivery system 清华大学 2023-07-18 CN claimed
CN-113912524-A Polypeptide compound containing sulfamide and synthesis method thereof 华东师范大学 2022-01-11 CN claimed
CN-106478771-A A kind of synthetic method of amino acid neural tetrapeptide 李世军 2017-03-08 CN claimed
CN-106279354-A A kind of synthetic method of amino acid neural dipeptides 温州医科大学 2017-01-04 CN claimed
US-9164106-B2 Determination of decreased metabolism of tryptophan in diagnosis of autism spectrum disorders GREENWOOD GENETIC CENTER, INC. (US) 2015-10-20 US claimed
US-20150183822-A1 ANGIOTENSIN-CONVERTING-ENZYME INHIBITING DIPEPTIDE YAMAKI CO., LTD. (JP) 2015-07-02 US claimed
CN-104583227-A Angiotensin-converting-enzyme inhibiting dipeptide YAMAKI CO LTD 2015-04-29 CN claimed
US-20130244273-A1 Determination of Decreased Metabolism of Tryptophan in Diagnosis of Autism Spectrum Disorders GREENWOOD GENETIC CENTER, INC. (US) 2013-09-19 US claimed
US-20100297680-A1 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE UNIVERSITY OF WASHINGTON (US) 2010-11-25 US claimed
US-20080261250-A1 Methods for Assessing the Risk for Development of Cardiovascular Disease UNIVERSITY OF WASHINGTON (US) 2008-10-23 US claimed
EP-1787116-A4 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE UNIV WASHINGTON (US) 2008-05-28 EP claimed
EP-1787116-A1 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE University of Washington (US) 2007-05-23 EP claimed
US-20060182652-A1 Methods for sterilizing biological materials using dipeptide stabilizers CLEARANT INC. 2006-08-17 US claimed
WO-2006014628-A1 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE UNIVERSITY OF WASHINGTON (US) 2006-02-09 WO claimed
EP-0555087-B1 Peritoneal dialysis solutions containing at least one dipeptide BAXTER INT (US) 1998-08-05 EP claimed
US-5597805-A Peritoneal dialysis solutions BAXTER INTERNATIONAL INC. (US) 1997-01-28 US claimed
US-4340592-A OLICOPEPTIDES FOR DIETARY PURPOSES ADIBI SIAMAK A 1982-07-20 US claimed
CN-117599013-A Nanometer composition, preparation method and application thereof 赣州和美药业股份有限公司 2024-02-27 CN disclosed
WO-2024015916-A2 4'-ALKYNE-2'-DEOXYCYTIDINE-BASED COMPOUNDS AND ANTI-CANCER USES THEREOF THOMAS JEFFERSON UNIVERSITY (US) 2024-01-18 WO disclosed
WO-2024006854-A2 HYPOIMMUNOGENIC BIOMIMETIC NANOVESICLE GENE EDITING SYSTEM FOR HIV INFECTION MALCOLM THOMAS (US) 2024-01-04 WO disclosed
CN-116507349-A Probiotic bacillus compositions and methods of use 生物编辑有限责任公司 2023-07-28 CN disclosed
CN-116444685-A Efficient controllable RNA delivery system 清华大学 2023-07-18 CN disclosed
US-20230158222-A1 DEVICES AND METHODS FOR TREATING A CORONAVIRUS INFECTION AND SYMPTOMS THEREOF AETHLON MEDICAL, INC. 2023-05-25 US disclosed
WO-2023064753-A1 DEVICES AND METHODS FOR TREATING A VIRAL INFECTION AND SYMPTOMS THEREOF AETHLON MEDICAL, INC. (US) 2023-04-20 WO disclosed
CN-115232192-B Azo type hypoxic response type dipeptide supramolecular monomer and preparation method and application thereof 济宁医学院 2023-03-28 CN disclosed
EP-4136453-A1 DEVICES AND METHODS FOR TREATING A CORONAVIRUS INFECTION AND SYMPTOMS THEREOF Aethlon Medical, Inc. (US) 2023-02-22 EP disclosed
CN-115232192-A Azo hypoxic response type dipeptide supramolecular monomer and preparation method and application thereof 济宁医学院 2022-10-25 CN disclosed
CN-114574612-A Methods and compositions for producing short shoot corn plants 孟山都技术有限公司 2022-06-03 CN disclosed
CN-113683661-B Dual-response dipeptide supramolecular polymer and preparation method and application thereof 济宁医学院 2022-03-11 CN disclosed
CN-113683661-B Dual-response dipeptide supramolecular polymer and preparation method and application thereof 济宁医学院 2022-03-11 CN disclosed
CN-107849570-B Methods and compositions for producing short shoot corn plants 孟山都技术有限公司 2022-02-15 CN disclosed
CN-113912524-A Polypeptide compound containing sulfamide and synthesis method thereof 华东师范大学 2022-01-11 CN disclosed
CN-113683661-A Dual-response dipeptide supramolecular polymer and preparation method and application thereof 济宁医学院 2021-11-23 CN disclosed
CN-113683661-A Dual-response dipeptide supramolecular polymer and preparation method and application thereof 济宁医学院 2021-11-23 CN disclosed
WO-2021211351-A1 DEVICES AND METHODS FOR TREATING A CORONAVIRUS INFECTION AND SYMPTOMS THEREOF AETHLON MEDICAL, INC. (US) 2021-10-21 WO disclosed
CN-113262288-A External activating fascia health-care bag and manufacturing and using methods thereof 厦门寿甫医疗科技有限公司 2021-08-17 CN disclosed
US-10590188-B2 Antibody QUEEN MARY UNIVERSITY OF LONDON (GB) 2020-03-17 US disclosed
US-10456736-B2 Method and apparatus for purification and treatment of air PALOZA LLC (US) 2019-10-29 US disclosed
US-20180244802-A1 ANTIBODY OR ANTIBODY FRAGMENT OF NON-IG SCAFFOLD BINDING TO A BINDING REGION OF AN ANTI-N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTIBODY DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN E.V. (DZNE) (DE) 2018-08-30 US disclosed
EP-3277083-A1 ORGAN PRESERVATION COMPOSITION TX Innovations B.V. (NL) 2018-02-07 EP disclosed
CN-107156652-A A kind of preparation method and its usage of multi-functional edible material 江苏大学 2017-09-15 CN disclosed
CN-107098952-A Antibacterial ring(Glycine tryptophan leucine D leucine valine asparagines)The preparation method of peptide 安徽工程大学 2017-08-29 CN disclosed
US-20170129948-A1 Antibody QUEEN MARY UNIVERSITY OF LONDON (GB) 2017-05-11 US disclosed
US-20170106333-A1 Method and Apparatus for Purification and Treatment of Air PALOZA LLC 2017-04-20 US disclosed
EP-3155012-A2 AUTOANTIBODIES ASSOCIATED WITH RHEUMATOID ARTHRITIS Queen Mary University of London (GB) 2017-04-19 EP disclosed
CN-104931628-B Fe3O4-COOH magnetic nano-material modified open tubular column as well as preparation method and application thereof 华南师范大学 2017-03-22 CN disclosed
CN-106478771-A A kind of synthetic method of amino acid neural tetrapeptide 李世军 2017-03-08 CN disclosed
US-20170016924-A1 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE UNIVERSITY OF WASHINGTON (US) 2017-01-19 US disclosed
CN-106279354-A A kind of synthetic method of amino acid neural dipeptides 温州医科大学 2017-01-04 CN disclosed
WO-2016159773-A1 ORGAN PRESERVATION COMPOSITION TX INNOVATIONS B.V. (NL) 2016-10-06 WO disclosed
CN-105992594-A Antibodies specific for enteroviruses that infect humans MAB探索私人有限公司 2016-10-05 CN disclosed
WO-2015189638-A2 ANTIBODY QUEEN MARY UNIVERSITY OF LONDON (GB) 2015-12-17 WO disclosed
US-9164106-B2 Determination of decreased metabolism of tryptophan in diagnosis of autism spectrum disorders GREENWOOD GENETIC CENTER, INC. (US) 2015-10-20 US disclosed
US-20150183822-A1 ANGIOTENSIN-CONVERTING-ENZYME INHIBITING DIPEPTIDE YAMAKI CO., LTD. (JP) 2015-07-02 US disclosed
CN-104583227-A Angiotensin-converting-enzyme inhibiting dipeptide YAMAKI CO LTD 2015-04-29 CN disclosed
CN-102046520-B Method of producing composition of hypochlorous acid and use thereof AQUILABS S A 2013-11-20 CN disclosed
US-8586759-B2 Methods and systems for synthesis of a D-aminoluciferin precursor and related compounds LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) 2013-11-19 US disclosed
US-20130244273-A1 Determination of Decreased Metabolism of Tryptophan in Diagnosis of Autism Spectrum Disorders GREENWOOD GENETIC CENTER, INC. (US) 2013-09-19 US disclosed
EP-2616481-A2 BIOPRODUCTION OF AROMATIC CHEMICALS FROM LIGNIN-DERIVED COMPOUNDS Aligna Technologies, Inc. (US) 2013-07-24 EP disclosed
WO-2012036884-A2 BIOPRODUCTION OF AROMATIC CHEMICALS FROM LIGNIN-DERIVED COMPOUNDS ALIGNA TECHNOLOGIES, INC. (US) 2012-03-22 WO disclosed
US-20120021923-A1 METHODS AND SYSTEMS TO DIAGNOSE A CONDITION IN AN INDIVIDUAL NATIONAL SCIENCE FOUNDATION 2012-01-26 US disclosed
US-20110275524-A1 METHODS AND SYSTEMS TO DETECT AN ACTIVE PROTEASE IN A SAMPLE NATIONAL SCIENCE FOUNDATION 2011-11-10 US disclosed
US-20110224442-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (LLNS) 2011-09-15 US disclosed
US-20110213124-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS LAWRENCE LIVERMORE NATIONAL SECURITY, LLC 2011-09-01 US disclosed
CN-102046520-A Method of producing composition of hypochlorous acid and use thereof AQUILABS S A 2011-05-04 CN disclosed
US-20100297680-A1 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE UNIVERSITY OF WASHINGTON (US) 2010-11-25 US disclosed
US-7749729-B2 Methods for assessing the risk for development of cardiovascular disease UNIVERSITY OF WASHINGTON (US) 2010-07-06 US disclosed
US-20100143364-A1 Chimeric Antibodies, Compositions and Methods for Treating Cocaine-Related Disorders VYBION, INC. (US) 2010-06-10 US disclosed
CN-100595277-C Form board stationary beta hair clip ring analog and use in bacteriophage exhibition POLYPHOR LTD 2010-03-24 CN disclosed
US-20080261250-A1 Methods for Assessing the Risk for Development of Cardiovascular Disease UNIVERSITY OF WASHINGTON (US) 2008-10-23 US disclosed
EP-1787116-A4 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE UNIV WASHINGTON (US) 2008-05-28 EP disclosed
EP-1536834-A4 DESIGN OF CHEMOKINE ANALOGS FOR THE TREATMENT OF HUMAN DISEASES CHEMOKINE THERAPEUTICS CORP (US) 2007-11-07 EP disclosed
CN-1984558-A Novel herbicide resistance gene DOW AGROSCIENCES LLC (US) 2007-06-20 CN disclosed
EP-1787116-A1 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE University of Washington (US) 2007-05-23 EP disclosed
CN-1918296-A Toxin complex proteins and genes from xenorhabdus bovienii DOW AGROSCIENCES LLC (US) 2007-02-21 CN disclosed
CN-1910280-A Template-fixed beta hairpin loop mimetics and their use in phage display POLYPHOR LTD (CH) 2007-02-07 CN disclosed
EP-0892054-B1 Clostridium perfringens vaccine INTERVET INT BV (NL) 2006-11-29 EP disclosed
WO-2006014628-A1 METHODS FOR ASSESSING THE RISK FOR DEVELOPMENT OF CARDIOVASCULAR DISEASE UNIVERSITY OF WASHINGTON (US) 2006-02-09 WO disclosed
CN-1684974-A Pesticidally active proteins and polynucleotides obtainable from paenibacillus species DOW AGROSCIENCES LLC (US) 2005-10-19 CN disclosed
EP-1536834-A2 DESIGN OF CHEMOKINE ANALOGS FOR THE TREATMENT OF HUMAN DISEASES Chemokine Therapeutics Corp. (US) 2005-06-08 EP disclosed
WO-2004024088-A2 DESIGN OF CHEMOKINE ANALOGS FOR THE TREATMENT OF HUMAN DISEASES CHEMOKINE THERAPEUTICS CORP. (US) 2004-03-25 WO disclosed
US-6610300-B1 Detoxified immunogenic derivatives of Clostridium perfringens beta -toxin or an immunogenic fragment thereof that have as a characteristic that they carry a mutation in the beta -toxin amino acid sequence, not found in the wild-type beta toxin AKZO NOBEL N.V. (NL) 2003-08-26 US disclosed
US-20030099689-A1 For aquatic animals, intended for oral administration and including mixture of synthetic peptide molecules representing 6-50% by weight of total formulation and include amino acid residues of all of the indispensable amino acids OHIO STATE RESEARCH FOUNDATION 2003-05-29 US disclosed
EP-0804931-B1 Peritoneal dialysis solutions and their use to minimize injury to mesothelial cells BAXTER INT (US) 2003-05-07 EP disclosed
EP-1007532-A1 OLIGONUCLEOTIDES FOR IDENTIFYING PRECURSORS OF AMIDATED POLYPEPTIDE HORMONES SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2000-06-14 EP disclosed
US-5955450-A Peritoneal dialysis solutions and methods usable to minimize the injury and adverse physiological effects caused by peritonitis BAXTER INTERNATIONAL INC. (US) 1999-09-21 US disclosed
EP-0726936-B1 LIQUID DETERGENTS WITH ORTHO-SUBSTITUTED PHENYLBORONIC ACIDS FOR INHIBITION OF PROTEOLYTIC ENZYME PROCTER & GAMBLE (US) 1999-05-19 EP disclosed
WO-1999010361-A1 OLIGONUCLEOTIDES FOR IDENTIFYING PRECURSORS OF AMIDATED POLYPEPTIDE HORMONES SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 1999-03-04 WO disclosed
EP-0892054-A1 Clostridium perfringens vaccine Akzo Nobel N.V. (NL) 1999-01-20 EP disclosed
EP-0555087-B1 Peritoneal dialysis solutions containing at least one dipeptide BAXTER INT (US) 1998-08-05 EP disclosed
EP-0804931-A2 Peritoneal dialysis solutions and their use to minimize injury to mesothelial cells BAXTER INTERNATIONAL INC. (US) 1997-11-05 EP disclosed
US-5597805-A Peritoneal dialysis solutions BAXTER INTERNATIONAL INC. (US) 1997-01-28 US disclosed
EP-0726936-A1 LIQUID DETERGENTS WITH ORTHO-SUBSTITUTED PHENYLBORONIC ACIDS FOR INHIBITION OF PROTEOLYTIC ENZYME THE PROCTER & GAMBLE COMPANY (US) 1996-08-21 EP disclosed
US-5438118-A Peptide mimics having constrained peptide backbone SMITHKLINE BEECHMAN CORP. (US) 1995-08-01 US disclosed
US-5436127-A Polypeptides for antibodies SHIN-ETSU CHEMICAL CO., LTD. (JP) 1995-07-25 US disclosed
WO-1995012655-A1 LIQUID DETERGENTS WITH ORTHO-SUBSTITUTED PHENYLBORONIC ACIDS FOR INHIBITION OF PROTEOLYTIC ENZYME THE PROCTER & GAMBLE COMPANY (US) 1995-05-11 WO disclosed
EP-0555087-A1 Peritoneal dialysis solutions containing at least one dipeptide BAXTER INTERNATIONAL INC. (US) 1993-08-11 EP disclosed
WO-1993014796-A1 PERITONEAL DIALYSIS COMPOSITION AND METHOD USABLE DURING AND AFTER PERITONITIS BAXTER INTERNATIONAL, INC. (US) 1993-08-05 WO disclosed
US-5194600-A Genes which participate in β-glucan assembly and use thereof ROYAL INSTITUTE FOR THE ADVANCEMENT OF LEARNING (CA) 1993-03-16 US disclosed
US-5061693-A Hexapeptides, anticoagulants MERCK & CO., INC. (US) 1991-10-29 US disclosed
US-4798778-A ETHYLENE POLYMER WITH CARBOXY ACID DERIVATIVE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-01-17 US disclosed
US-4393201-A DEOXYRIBONUCLEIC ACID THE WISTAR INSTITUTE (US) 1983-07-12 US disclosed
US-4393201-A DEOXYRIBONUCLEIC ACID THE WISTAR INSTITUTE (US) 1983-07-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224442-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS HCCS, HLCS, GLUL ADORA3 2359/4885KDM4E 4005/4885MAPT 4518/4885
US-20100143364-A1 Chimeric Antibodies, Compositions and Methods for Treating Cocaine-Related Disorders CES2, CHRNA5, CHRNA3 ADORA3 510/4885KDM4E 1096/4885MAPT 61/4885
US-20110213124-A1 METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS HCCS, HLCS, GLUL ADORA3 2359/4885KDM4E 4005/4885MAPT 4518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.