Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | GLI1 | P08151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL8720004 | 1.00 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP7 | |
| Proline SCHEMBL3100537 | 1.00 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP7 | |
| Proline SCHEMBL1702869 | 1.00 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP7 | |
| Proline SCHEMBL5860492 | 1.00 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP7 | |
| Proline SCHEMBL3089157 | 1.00 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP7 | |
| Proline SCHEMBL27596714 | 1.00 | NOS2 (0.37) | NOS2NOS3NOS1PRCPDPP7 | |
| Valine SCHEMBL3048383 | 0.93 | SLC7A5 (0.41) | NOS2NOS3NOS1PRCPDPP7 | |
| Valine SCHEMBL5801852 | 0.93 | SLC7A5 (0.41) | NOS2NOS3NOS1PRCPDPP7 | |
| Valine SCHEMBL4612496 | 0.93 | SLC7A5 (0.41) | NOS2NOS3NOS1PRCPDPP7 | |
| Valine SCHEMBL2189978 | 0.93 | SLC7A5 (0.41) | NOS2NOS3NOS1PRCPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458197-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150004184-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2015-01-01 | — | — | US | disclosed |
| US-8871707-B2 | Elastin producing fibroblast formulations and methods of using the same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-10-28 | — | — | US | disclosed |
| US-8828927-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2014-09-09 | — | — | US | disclosed |
| US-20130295122-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2013-11-07 | — | — | US | disclosed |
| US-8461113-B2 | Elastin digest compositions and methods utilizing same | HUMAN MATRIX SCIENCES, LLC (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110319283-A1 | OLIGONUCLEOTIDES CAPABLE OF DISCRIMINATING BETWEEN NUCLEIC ACID SEQUENCES THAT COMPRISE A CONSERVED SEQUENCE | TRILLION GENOMICS LIMITED (GB) | 2011-12-29 | — | — | US | disclosed |
| US-20110172115-A1 | CHARACTERISING PLANAR SAMPLES BY MASS SPECTROMETRY | TRILLION GENOMICS LIMITED (GB) | 2011-07-14 | — | — | US | disclosed |
| US-20110081322-A1 | ELASTIN PRODUCING FIBROBLAST FORMULATIONS AND METHODS OF USING THE SAME | NULASTIN, INC. | 2011-04-07 | — | — | US | disclosed |
| US-20090281044-A1 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME | NULASTIN, INC. | 2009-11-12 | — | — | US | disclosed |