SCHEMBL167563

SCHEMBL167563

CSc1nc(N)c(C#N)s1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.39
KDM4E B2RXH2 4/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
ALDH1A1 P00352 2/20 0.38
KEAP1 Q14145 1/20 0.36
HTT P42858 4/20 0.33
MAPT P10636 3/20 0.33
NPC1 O15118 1/20 0.33
USP2 O75604 1/20 0.33
RAB9A P51151 1/20 0.33
NPSR1 Q6W5P4 2/20 0.32
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
HSD17B10 Q99714 2/20 0.31
MAPK1 P28482 2/20 0.31
ALOX15 P16050 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9826113 0.79 ALDH1A1 (0.43) LMNAKDM4ESMN1; SMN2ALDH1A1HTT
SCHEMBL9826271 0.77 KDM4E (0.38) LMNAKDM4ESMN1; SMN2ALDH1A1HTT
SCHEMBL9827215 0.76 SMN1; SMN2 (0.41) KDM4ESMN1; SMN2ALDH1A1HTTNPC1
SCHEMBL811232 0.76 KMT2A (0.50) LMNASMN1; SMN2ALDH1A1HTTMAPT
SCHEMBL9827017 0.74 ALDH1A1 (0.43) LMNAKDM4ESMN1; SMN2ALDH1A1HTT
SCHEMBL11564103 0.74
SCHEMBL10570024 0.72 MAOA (0.41) KDM4EALDH1A1MAPTNPSR1MEN1
SCHEMBL8555731 0.72
SCHEMBL11583412 0.68
SCHEMBL6845036 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4705294-A1 FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS CCR4 MODULATORS Aurigene Oncology Limited (IN) 2026-03-11 EP disclosed
WO-2024228132-A1 FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS CCR4 MODULATORS AURIGENE ONCOLOGY LIMITED (IN) 2024-11-07 WO disclosed
EP-3372601-B1 NOVEL BICYCLIC HETEROCYCLIC COMPOUND MITSUBISHI TANABE PHARMA CORP (JP) 2022-09-21 EP disclosed
US-10793582-B2 Bicyclic heterocyclic compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2020-10-06 US disclosed
US-10793582-B2 Bicyclic heterocyclic compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2020-10-06 US disclosed
US-20190233438-A1 NOVEL BICYCLIC HETEROCYCLIC COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-08-01 US disclosed
US-20190233438-A1 NOVEL BICYCLIC HETEROCYCLIC COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-08-01 US disclosed
EP-3372601-A1 NOVEL BICYCLIC HETEROCYCLIC COMPOUND Mitsubishi Tanabe Pharma Corporation (JP) 2018-09-12 EP disclosed
EP-2432321-B1 THIAZOLOPYRIMIDINONE DERIVATIVES AS PI3 KINASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2017-06-14 EP disclosed
US-9434731-B2 Imidazo-, pyrazolopyrazines and imidazotriazines and their use BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-09-06 US disclosed
WO-2007019191-A2 THIAZOLOPYRIMIDINE KINASE INHIBITORS JANSSEN PHARMACEUTICA, N.V. (BE) 2007-02-15 WO disclosed
WO-2007019191-A2 THIAZOLOPYRIMIDINE KINASE INHIBITORS JANSSEN PHARMACEUTICA, N.V. (BE) 2007-02-15 WO disclosed
EP-0169813-B1 PHOTOGRAPHIC RECORDING MATERIAL FOR THE SILVER DYE-BLEACHING PROCESS CIBA-GEIGY AG (CH) 1992-04-15 EP disclosed
EP-0301613-B1 THIAZOLE COMPOUNDS HAVING FUNGICIDAL ACTIVITY DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1991-07-10 EP disclosed
US-4889863-A NONPHYTOTOXIC; SEEDS, SOILS DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1989-12-26 US disclosed
EP-0301613-A1 Thiazole compounds having fungicidal activity DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1989-02-01 EP disclosed
US-4743683-A FOR DYE BLEACH PROCESS, PHOTOGRAPHY CIBA-GEIGY AG (CH) 1988-05-10 US disclosed
US-4661437-A COLORFASTNESS CIBA-GEIGY AG (CH) 1987-04-28 US disclosed
EP-0169813-A2 Photographic recording material for the silver dye-bleaching process CIBA-GEIGY AG (CH) 1986-01-29 EP disclosed
US-4153607-A Process for the production of 4,5-disubstituted thiazoles BASF AKTIENGESELLSCHAFT (DE) 1979-05-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190233438-A1 NOVEL BICYCLIC HETEROCYCLIC COMPOUND KAT2A, KAT7, KAT5 LMNA 4276/4885KDM4E 418/4885SMN1; SMN2 4513/4885
US-10793582-B2 Bicyclic heterocyclic compound KAT2A, KAT7, KAT5 LMNA 4153/4885KDM4E 383/4885SMN1; SMN2 4455/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.