Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16756277 | 0.91 | METAP2 (0.38) | TLR7GRIN1GRIN2BRETDRD4 | |
| SCHEMBL16756302 | 0.89 | PPARD (0.40) | TLR7GRIN1GRIN2BRETTNF | |
| SCHEMBL16756387 | 0.89 | HTR6 (0.42) | TLR7GRIN1GRIN2BSLC6A4TLR9 | |
| Hydrochloric Acid SCHEMBL16756445 | 0.88 | PPARD (0.40) | GRIN1GRIN2BTNFPPARDPPARA | |
| SCHEMBL16756259 | 0.88 | PPARD (0.40) | TLR7RETDRD4HTR1AHTR2A | |
| SCHEMBL15560202 | 0.87 | ITGB2 (0.37) | TLR7GRIN1GRIN2BRETHTR1A | |
| SCHEMBL20278327 | 0.83 | TLR9 (0.42) | TLR7TLR9TLR8 | |
| SCHEMBL24060190 | 0.82 | HTR6 (0.41) | TLR7RETTLR9TLR8 | |
| SCHEMBL16756580 | 0.81 | TLR7 (0.44) | TLR7GRIN1GRIN2BPPARDPPARA | |
| SCHEMBL15560205 | 0.80 | GRIN1 (0.47) | TLR7GRIN1GRIN2BTNFPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550737-B2 | TNF -α modulating benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2017-01-24 | — | — | US | disclosed |
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | UCB BIOPHARMA SPRL (BE) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152065-A1 | TNF -Alpha Modulating Benzimidazoles | TNF, TNFRSF1A, NFKBIA | TLR7 3878/4885GRIN1 1207/4885GRIN2B 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.