Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.53 |
| ▸ | ITGAL | P20701 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | ADK | P55263 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.42 |
| ▸ | WNT3A | P56704 | 2/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL21806572 | 0.92 | AHR (0.63) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL28087845 | 0.83 | AHR (0.77) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL2170920 | 0.82 | TRPA1 (0.59) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL16757645 | 0.82 | TRPA1 (0.63) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL5174731 | 0.80 | TRPA1 (0.61) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL28576095 | 0.80 | TRPA1 (0.61) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL31206792 | 0.80 | TRPA1 (0.61) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL28976104 | 0.80 | TRPA1 (0.52) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL384964 | 0.79 | TRPA1 (0.71) | AHRTRPA1CA1CA2ITGB2 | |
| Indole SCHEMBL28479409 | 0.79 | TRPA1 (0.77) | AHRTRPA1CA1CA2ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115504924-A | Hydrazino-pyrrolo compounds and methods for forming conjugates | 雷德伍德生物科技股份有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-105744935-B | Hydrazino-pyrrolo compounds and methods for forming conjugates | 雷德伍德生物科技股份有限公司 | 2022-09-30 | — | — | CN | disclosed |
| US-20220153696-A1 | Hydrazinyl-Pyrrolo Compounds and Methods for Producing a Conjugate | ARES CAPITAL CORPORATION, AS COLLATERAL AGENT | 2022-05-19 | — | — | US | disclosed |
| US-11180451-B2 | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate | REDWOOD BIOSCIENCE, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200317610-A1 | Hydrazinyl-Pyrrolo Compounds and Methods for Producing a Conjugate | ARES CAPITAL CORPORATION, AS COLLATERAL AGENT | 2020-10-08 | — | — | US | disclosed |
| US-10604483-B2 | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate | REDWOOD BIOSCIENCE, INC. (US) | 2020-03-31 | — | — | US | disclosed |
| US-10464894-B2 | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate | REDWOOD BIOSCIENCES, INC. (US) | 2019-11-05 | — | — | US | disclosed |
| US-20170049907-A1 | HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE | CATALENT PHARMA SOLUTIONS, LLC | 2017-02-23 | — | — | US | disclosed |
| US-9493413-B2 | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate | REDWOOD BIOSCIENCE, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| EP-3074010-A1 | HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE | Redwood Bioscience, Inc. (US) | 2016-10-05 | — | — | EP | disclosed |
| CN-105744935-A | Hydrazino-pyrrolo compounds and methods for forming conjugates | 雷德伍德生物科技股份有限公司 | 2016-07-06 | — | — | CN | disclosed |
| US-20150157736-A1 | HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE | R.P. SCHERER TECHNOLOGIES, LLC | 2015-06-11 | — | — | US | disclosed |
| WO-2015081282-A1 | HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE | REDWOOD BIOSCIENCE, INC. (US) | 2015-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150157736-A1 | HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE | DNPEP, QPCT, PDS5A | SLC6A2 2807/4885SLC6A3 1624/4885AHR 2047/4885 |
| US-20220153696-A1 | Hydrazinyl-Pyrrolo Compounds and Methods for Producing a Conjugate | DNPEP, QPCT, PDS5A | SLC6A2 2807/4885SLC6A3 1624/4885AHR 2047/4885 |
| US-20170049907-A1 | HYDRAZINYL-PYRROLO COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE | DNPEP, QPCT, PDS5A | SLC6A2 2807/4885SLC6A3 1624/4885AHR 2047/4885 |
| US-11180451-B2 | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate | DNPEP, QPCT, PDS5A | SLC6A2 2807/4885SLC6A3 1624/4885AHR 2047/4885 |
| US-10464894-B2 | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate | DNPEP, QPCT, PDS5A | SLC6A2 2807/4885SLC6A3 1624/4885AHR 2047/4885 |
| US-10604483-B2 | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate | DNPEP, QPCT, PDS5A | SLC6A2 2807/4885SLC6A3 1624/4885AHR 2047/4885 |
| US-20200317610-A1 | Hydrazinyl-Pyrrolo Compounds and Methods for Producing a Conjugate | DNPEP, QPCT, PDS5A | SLC6A2 2807/4885SLC6A3 1624/4885AHR 2047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.