⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1675933 | 0.98 | KDM4E (0.35) | — | |
| SCHEMBL18943050 | 0.83 | DGAT1 (0.33) | — | |
| SCHEMBL3322447 | 0.77 | — | — | |
| SCHEMBL3608850 | 0.77 | — | — | |
| SCHEMBL1583583 | 0.77 | — | — | |
| SCHEMBL15114224 | 0.76 | DGAT1 (0.41) | — | |
| SCHEMBL761738 | 0.76 | ALOX15 (0.42) | — | |
| SCHEMBL29505908 | 0.75 | — | — | |
| SCHEMBL21585916 | 0.75 | — | — | |
| SCHEMBL124837 | 0.75 | DGAT1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082111-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-04-07 | — | — | US | claimed |
| EP-3583105-B1 | PYRROLO [1,2-B]PYRIDAZINE DERIVATIVES | GILEAD SCIENCES INC (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-110300754-A | Pyrrolo [1,2-b ] pyridazine derivatives | 吉利德科学公司 | 2019-10-01 | — | — | CN | disclosed |
| US-10336762-B2 | Pyrrolo[1,2-b]pyridazine derivatives | GILEAD SCIENCES, INC. (US) | 2019-07-02 | — | — | US | disclosed |
| WO-2018152368-A1 | PYRROLO [1,2-B] PYRIDAZINE DERIVATIVES | GILEAD SCIENCES, INC. (US) | 2018-08-23 | — | — | WO | disclosed |
| EP-2564850-B1 | Polo-like kinase inhibitors | TAKEDA PHARMACEUTICAL (JP) | 2014-08-13 | — | — | EP | disclosed |
| CN-103122001-A | Polo-like kinase inhibitors | TAKEDA PHARMACEUTICAL | 2013-05-29 | — | — | CN | disclosed |
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |
| US-8318727-B2 | Polo-like kinase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-11-27 | — | — | US | disclosed |
| EP-2197442-B1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2012-09-12 | — | — | EP | disclosed |
| EP-2205241-A1 | POLO-LIKE KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-07-14 | — | — | EP | disclosed |
| EP-2197442-A1 | POLO-LIKE KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-23 | — | — | EP | disclosed |
| US-20090281092-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-11-12 | — | — | US | disclosed |
| WO-2009042711-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009042806-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |
| US-20050059611-A1 | Glucagon antagonists/inverse agonists | NOVO NORDISK A/S (DK) | 2005-03-17 | — | — | US | disclosed |
| US-6821960-B2 | Glucagon antagonists/inverse agonists | NOYO NORDISK PHARMACEUTICALS, INC. | 2004-11-23 | — | — | US | disclosed |
| EP-1345891-A1 | GLUCAGON ANTAGONIST/INVERSE AGONIST | Novo Nordisk A/S (DK) | 2003-09-24 | — | — | EP | disclosed |
| US-20030027849-A1 | Glucagon antagonists/inverse agonists | NOVO NORDISK A/S (DK) | 2003-02-06 | — | — | US | disclosed |
| WO-2002040446-A1 | GLUCAGON ANTAGONIST/INVERSE AGONIST | NOVO NORDISK A/S (DK) | 2002-05-23 | — | — | WO | disclosed |