Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.58 |
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 6/20 | 0.46 |
| ▸ | GRK2 | P25098 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16758521 | 0.87 | MET (0.58) | METGRK5GRK2KCNH2FLT3 | |
| SCHEMBL29631682 | 0.81 | MET (0.64) | METJAK2JAK1JAK3GRK5 | |
| SCHEMBL28346361 | 0.81 | MET (0.64) | METJAK2JAK1JAK3GRK5 | |
| SCHEMBL16758552 | 0.80 | MET (0.66) | METJAK2JAK1JAK3GRK5 | |
| SCHEMBL30387867 | 0.78 | MET (0.57) | METJAK2JAK1JAK3GRK5 | |
| SCHEMBL29964366 | 0.78 | JAK2 (0.61) | METJAK2JAK1JAK3ABL1 | |
| SCHEMBL18861159 | 0.78 | MET (0.57) | METJAK2JAK1JAK3GRK5 | |
| SCHEMBL16758440 | 0.78 | MET (0.60) | METJAK2JAK1JAK3GRK5 | |
| SCHEMBL21776583 | 0.77 | MET (0.59) | METJAK2JAK1JAK3GRK5 | |
| SCHEMBL29631656 | 0.77 | MET (0.59) | METJAK2JAK1JAK3GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074390-A2 | AMINOPYRIDINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | SignalChem Lifesciences Corporation (CA) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015081257-A2 | AMINOPYRIDINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS | SIGNALCHEM LIFESCIENCES CORPORATION (CA) | 2015-06-04 | — | — | WO | disclosed |