SCHEMBL1675974

SCHEMBL1675974

O=C(O)[C@H]1[C@@H](c2ccccc2)CCN1C(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FABP5 Q01469 3/20 0.50
FABP7 O15540 2/20 0.50
TACR1 P25103 1/20 0.41
KMT2A Q03164 2/20 0.40
EPHX2 P34913 1/20 0.38
OPRD1 P41143 1/20 0.38
MC4R P32245 1/20 0.36
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
MDM4 O15151 1/20 0.35
TP53 P04637 1/20 0.35
SLC6A2 P23975 2/20 0.35
SLC6A4 P31645 2/20 0.35
SLC6A3 Q01959 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1675971 1.00 FABP5 (0.50) FABP5FABP7TACR1KMT2AEPHX2
SCHEMBL31582094 0.90 FABP5 (0.43) FABP5FABP7KMT2AEPHX2MDM4
SCHEMBL31524267 0.90 FABP5 (0.43) FABP5FABP7KMT2AEPHX2MDM4
SCHEMBL2906513 0.88 FABP5 (0.42) FABP5FABP7KMT2AEPHX2SLC6A4
SCHEMBL7202660 0.88 FABP5 (0.52) FABP5FABP7KMT2AEPHX2OPRD1
SCHEMBL1827945 0.88 FABP5 (0.52) FABP5FABP7KMT2AEPHX2OPRD1
SCHEMBL7202664 0.88 FABP5 (0.52) FABP5FABP7KMT2AEPHX2OPRD1
SCHEMBL30686169 0.86 FABP5 (0.47) FABP5FABP7KMT2AEPHX2OPRD1
SCHEMBL30686135 0.86 FABP5 (0.47) FABP5FABP7KMT2AEPHX2OPRD1
SCHEMBL3423135 0.86 FABP5 (0.47) FABP5FABP7KMT2AEPHX2OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110092445-A1 Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses ABBOTT LABORATORIES (US) 2011-04-21 US disclosed
EP-2303920-A2 AMYLOID ß PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PROCESSES FOR PREPARING AND COMPOSITIONS COMPRISING SAID ANALOGUES OR OLIGOMERS, AND THEIR USES Abbott Laboratories (US) 2011-04-06 EP disclosed
WO-2010011947-A2 AMYLOID ß PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PROCESSES FOR PREPARING AND COMPOSITIONS COMPRISING SAID ANALOGUES OR OLIGOMERS, AND THEIR USES ABBOTT LABORATORIES (US) 2010-01-28 WO disclosed
US-5856439-A ANTICANCER AGENT RHONE-POULENC RORER S.A. (FR) 1999-01-05 US disclosed
EP-0808328-A1 NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-11-26 EP disclosed
WO-1996024611-A1 NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1996-08-15 WO disclosed