Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.40 |
| ▸ | RXRA | P19793 | 8/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | DCK | P27707 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1676032 | 1.00 | PTGS2 (0.43) | PTGS2CAMKK2NR1H2RXRANR1H3 | |
| SCHEMBL1677004 | 0.90 | NR1H2 (0.48) | PTGS2NR1H2RXRANR1H3PTGS1 | |
| SCHEMBL1677000 | 0.90 | NR1H2 (0.48) | PTGS2NR1H2RXRANR1H3PTGS1 | |
| SCHEMBL1676065 | 0.86 | NR1H2 (0.44) | PTGS2CAMKK2NR1H2RXRANR1H3 | |
| SCHEMBL1676067 | 0.86 | NR1H2 (0.44) | PTGS2CAMKK2NR1H2RXRANR1H3 | |
| SCHEMBL1676318 | 0.83 | NR1H2 (0.45) | PTGS2CAMKK2NR1H2RXRANR1H3 | |
| SCHEMBL1676316 | 0.83 | NR1H2 (0.45) | PTGS2CAMKK2NR1H2RXRANR1H3 | |
| SCHEMBL1676419 | 0.79 | MARS1 (0.41) | PTGS2CAMKK2NR1H2RXRANR1H3 | |
| SCHEMBL1676417 | 0.79 | MARS1 (0.41) | PTGS2CAMKK2NR1H2RXRANR1H3 | |
| SCHEMBL1676667 | 0.76 | NR1H2 (0.48) | PTGS2NR1H2RXRANR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | TRANSTECH PHARMA, INC. (US) | 2011-04-21 | — | — | US | claimed |
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | TRANSTECH PHARMA, INC. (US) | 2011-04-21 | — | — | US | disclosed |
| EP-1730118-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | Transtech Pharma, Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005080346-A1 | SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE | TRANSTECH PHARMA, INC. (US) | 2005-09-01 | — | — | WO | disclosed |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092553-A1 | Substituted Azole Derivatives, Compositions, and Methods of Use | PTPRO, PTPN5, PTPRE | PTGS2 1321/4885CAMKK2 1387/4885NR1H2 2585/4885 |
| US-20050187277-A1 | Substituted azole derivatives, compositions, and methods of use | PTPRO, PTPN5, PTPRE | PTGS2 1321/4885CAMKK2 1387/4885NR1H2 2585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.