Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 1.00 |
| ▸ | RET | P07949 | 12/20 | 1.00 |
| ▸ | KIF5B | P33176 | 11/20 | 1.00 |
| ▸ | FLT1 | P17948 | 6/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.73 |
| ▸ | FLT4 | P35916 | 2/20 | 0.73 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.73 |
| ▸ | RAF1 | P04049 | 1/20 | 0.72 |
| ▸ | BRAF | P15056 | 1/20 | 0.72 |
| ▸ | EGFR | P00533 | 4/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16760421 | 0.99 | KDR (0.98) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL21557366 | 0.91 | KDR (0.83) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL6669352 | 0.86 | KDR (0.77) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL18158611 | 0.84 | KDR (0.82) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL3012896 | 0.84 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL7870603 | 0.84 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL29365791 | 0.84 | KDR (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| SCHEMBL15052315 | 0.84 | RAF1 (1.00) | KDRRETKIF5BRAF1BRAF | |
| SCHEMBL16760370 | 0.83 | RET (1.00) | KDRRETKIF5BFLT1FGFR1 | |
| Hydrochloric Acid SCHEMBL7867640 | 0.83 | KDR (0.98) | KDRRETKIF5BFLT1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015079251-A1 | QUINAZOLINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-06-04 | — | — | WO | claimed |
| WO-2015079251-A1 | QUINAZOLINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-06-04 | — | — | WO | disclosed |