Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 8/20 | 0.38 |
| ▸ | SRC | P12931 | 8/20 | 0.38 |
| ▸ | ABL2 | P42684 | 8/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16760543 | 1.00 | ABL1 (0.38) | ABL1SRCABL2PDE4BPDE4A | |
| SCHEMBL5048852 | 0.88 | GPR119 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5048849 | 0.88 | GPR119 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5025339 | 0.88 | ABL1 (0.47) | ABL1SRCABL2KDR | |
| SCHEMBL5025337 | 0.88 | ABL1 (0.47) | ABL1SRCABL2KDR | |
| SCHEMBL4288363 | 0.84 | CHRNB4 (0.37) | ABL1SRCABL2 | |
| SCHEMBL4288369 | 0.84 | CHRNB4 (0.37) | ABL1SRCABL2 | |
| SCHEMBL16760505 | 0.80 | HPGD (0.46) | — | |
| SCHEMBL16760431 | 0.80 | HPGD (0.46) | — | |
| SCHEMBL5026019 | 0.77 | ALDH1A1 (0.35) | ABL1SRCABL2PDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015079251-A1 | QUINAZOLINE COMPOUNDS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-06-04 | — | — | WO | disclosed |