Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Diphenylmethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylmethane SCHEMBL27961286 | 0.92 | CALM1 (0.55) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL1014928 | 0.92 | CALM1 (0.55) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL29135359 | 0.84 | CALM1 (0.50) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL15415 | 0.83 | CALM1 (0.67) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL28457396 | 0.83 | CALM1 (0.67) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL9449990 | 0.83 | CALM1 (0.67) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL7497963 | 0.83 | CALM1 (0.67) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL28763356 | 0.83 | CALM1 (0.67) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL465158 | 0.83 | CALM1 (0.67) | CALM1LTA4HPLA2G10PLA2G2APRSS1 | |
| Diphenylmethane SCHEMBL333766 | 0.83 | CALM1 (0.67) | CALM1LTA4HPLA2G10PLA2G2APRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9778402-B2 | Light reflective film and light reflector produced using the same | Konica Minolta, Inc. (JP) | 2017-10-03 | — | — | US | disclosed |
| US-20150219810-A1 | LIGHT REFLECTIVE FILM AND LIGHT REFLECTOR PRODUCED USING THE SAME | Konica Minolta, Inc. (JP) | 2015-08-06 | — | — | US | disclosed |
| EP-2881769-A1 | LIGHT-REFLECTIVE FILM, AND LIGHT REFLECTOR PRODUCED USING SAME | Konica Minolta, Inc. (JP) | 2015-06-10 | — | — | EP | disclosed |