Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | GHSR | Q92847 | 5/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.43 |
| ▸ | MC5R | P33032 | 1/20 | 0.43 |
| ▸ | MC3R | P41968 | 1/20 | 0.43 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.42 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL22587382 | 0.90 | KDM4E (0.61) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL27671666 | 0.90 | KDM4E (0.61) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL27093065 | 0.90 | KDM4E (0.61) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28466764 | 0.90 | KDM4E (0.61) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28880639 | 0.89 | KDM4E (0.45) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL29151523 | 0.88 | KDM4E (0.54) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL25306742 | 0.88 | KDM4E (0.50) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL19924290 | 0.88 | KDM4E (0.50) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL9220819 | 0.88 | KDM4E (0.65) | KDM4EMAPTMEN1LMNAMPO | |
| Dl-Tryptophan SCHEMBL28079286 | 0.87 | KDM4E (0.43) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150189898-A1 | COFFEE SUBSTITUTE | KIRIN BEVERAGE COMPANY, LIMITED (JP) | 2015-07-09 | — | — | US | disclosed |
| EP-2880988-A1 | COFFEE SUBSTITUTE | Kirin Beverage Company, Limited (JP) | 2015-06-10 | — | — | EP | disclosed |