Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | PTH1R | Q03431 | 2/20 | 0.40 |
| ▸ | GHSR | Q92847 | 3/20 | 0.40 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 2/20 | 0.40 |
| ▸ | MC5R | P33032 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL16762301 | 0.89 | KDM4E (0.50) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL29220361 | 0.89 | KISS1R (0.47) | GHSRKISS1R | |
| Tryptophan SCHEMBL28979632 | 0.89 | KDM4E (0.45) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28985159 | 0.87 | KDM4E (0.53) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28079286 | 0.87 | KDM4E (0.43) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL28144336 | 0.86 | RXFP1 (0.41) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL18614910 | 0.86 | KDM4E (0.52) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL18614911 | 0.86 | KDM4E (0.52) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL22587382 | 0.86 | KDM4E (0.61) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28466764 | 0.86 | KDM4E (0.61) | KDM4EMEN1LMNAMPOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590915-A | Artificial antibacterial peptide CAH, preparation method and application thereof | 陕西科技大学 | 2019-12-20 | — | — | CN | disclosed |