Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | KISS1R | Q969F8 | 9/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | IL1RN | P18510 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | MAGI3 | Q5TCQ9 | 1/20 | 0.38 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL25306742 | 0.93 | KDM4E (0.50) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28338052 | 0.89 | KDM4E (0.55) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL16762301 | 0.87 | KDM4E (0.50) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28880639 | 0.87 | KDM4E (0.45) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL28979632 | 0.87 | KDM4E (0.45) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29151523 | 0.86 | KDM4E (0.54) | KDM4EMEN1LMNAMPOMAPT | |
| Tryptophan SCHEMBL11385378 | 0.86 | KDM4E (0.40) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL28985159 | 0.85 | KDM4E (0.53) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL27944528 | 0.85 | KDM4E (0.45) | KDM4EMEN1LMNAMPOMAPT | |
| Dl-Tryptophan SCHEMBL29062048 | 0.85 | OPRM1 (0.47) | KDM4EMEN1LMNAMPOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105765067-A | Modified beta-galactosidase | 天野酶株式会社 | 2016-07-13 | — | — | CN | claimed |
| CN-105765067-A | Modified beta-galactosidase | 天野酶株式会社 | 2016-07-13 | — | — | CN | disclosed |