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SCHEMBL16765446

SCHEMBL16765446

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nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.46
▸ GAA P10253 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ TGFBR1 P36897 3/20 0.44
▸ ACE P12821 1/20 0.42
▸ MME P08473 2/20 0.42
▸ TDP1 Q9NUW8 1/20 0.41
▸ CTSS P25774 6/20 0.41
▸ CTSK P43235 6/20 0.41
▸ CTSL P07711 1/20 0.40
▸ CTSB P07858 1/20 0.40
▸ PPARA Q07869 2/20 0.38
▸ PPARG P37231 1/20 0.38
▸ CAPN1 P07384 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16790408 1.00 MEN1 (0.46) MEN1GAAKMT2ATGFBR1ACE
SCHEMBL31488854 0.97 MEN1 (0.44) MEN1GAAKMT2ATGFBR1ACE
SCHEMBL24130649 0.88 MEN1 (0.46) MEN1GAAKMT2AACETDP1
SCHEMBL5073478 0.87 BACE1 (0.40) MEN1GAAKMT2AMMECTSS
SCHEMBL13884482 0.86 MEN1 (0.45) MEN1GAAKMT2AACECTSS
SCHEMBL7393270 0.86 MEN1 (0.45) MEN1GAAKMT2AACECTSS
SCHEMBL22987316 0.86 MEN1 (0.45) MEN1GAAKMT2AACETDP1
SCHEMBL5014045 0.86 KLK5 (0.41) MEN1GAAKMT2AMMETDP1
SCHEMBL29880096 0.86 MAPT (0.46) MEN1GAAKMT2AACETDP1
SCHEMBL3374088 0.86 KLK5 (0.41) MEN1GAAKMT2AMMETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116410145-A Preparation method of MRTX849 intermediate 上海泓博智源医药股份有限公司 2023-07-11 — — CN disclosed
CN-107406480-B Peptide synthesis method JITSUBO株式会社 2022-06-24 — — CN disclosed
EP-3313857-B1 POLYMER-CYCLODEXTRIN-LIPID CONJUGATES WU NIAN (US) 2021-01-06 — — EP disclosed
US-10835608-B2 Polymer-carbohydrate conjugates for drug delivery technology LIPOSEUTICALS INC 2020-11-17 — — US disclosed
US-10064954-B2 Polymer-cyclodextrin-lipid conjugates LIPOSEUTICALS INC 2018-09-04 — — US disclosed
EP-3313857-A1 POLYMER-CYCLODEXTRIN-LIPID CONJUGATES Wu, Nian (US) 2018-05-02 — — EP disclosed
WO-2016209732-A1 POLYMER-CYCLODEXTRIN-LIPID CONJUGATES WU NIAN (US) 2016-12-29 — — WO disclosed
US-20160375150-A1 POLYMER-CYCLODEXTRIN-LIPID CONJUGATES LIPOSEUTICALS INC 2016-12-29 — — US disclosed
US-20150157721-A1 POLYMER-CARBOHYDRATE CONJUGATES FOR DRUG DELIVERY TECHNOLOGY LIPOSEUTICALS INC 2015-06-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10835608-B2 Polymer-carbohydrate conjugates for drug delivery technology LIPC, FABP4, CETP MEN1 2733/4885GAA 1518/4885KMT2A 1977/4885
US-10064954-B2 Polymer-cyclodextrin-lipid conjugates CETP, FABP4, PLIN3 MEN1 3960/4885GAA 395/4885KMT2A 4200/4885
US-20150157721-A1 POLYMER-CARBOHYDRATE CONJUGATES FOR DRUG DELIVERY TECHNOLOGY LIPC, FABP4, CETP MEN1 2733/4885GAA 1518/4885KMT2A 1977/4885
US-20160375150-A1 POLYMER-CYCLODEXTRIN-LIPID CONJUGATES CETP, FADS2, FABP4 MEN1 3921/4885GAA 580/4885KMT2A 3966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.