⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16766255 | 0.79 | ALDH1A1 (0.36) | — | |
| SCHEMBL16765834 | 0.73 | CHRM2 (0.33) | — | |
| SCHEMBL16765836 | 0.73 | CHRM2 (0.33) | — | |
| SCHEMBL15245656 | 0.71 | HSD11B1 (0.39) | — | |
| Trifluoroacetic Acid SCHEMBL16765660 | 0.66 | KDM1A (0.34) | — | |
| Trifluoroacetic Acid SCHEMBL16765657 | 0.66 | KDM1A (0.34) | — | |
| SCHEMBL19713060 | 0.63 | ALDH1A1 (0.40) | — | |
| SCHEMBL19733325 | 0.63 | ALDH1A1 (0.40) | — | |
| SCHEMBL21640480 | 0.63 | — | — | |
| SCHEMBL16635692 | 0.62 | HSD11B1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800748-B1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2017-03-29 | — | — | EP | disclosed |
| US-9453014-B2 | Cyclic amide derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase and uses thereof | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2016-09-27 | — | — | US | disclosed |
| US-20150158860-A1 | CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2015-06-11 | — | — | US | disclosed |