Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | MDM4 | O15151 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 4/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16755584 | 1.00 | MAPT (0.62) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL15563073 | 1.00 | MAPT (0.62) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL19840318 | 0.94 | MAPT (0.56) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16755571 | 0.85 | MAPT (0.63) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16769901 | 0.85 | MAPT (0.63) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16755572 | 0.85 | MAPT (0.63) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16755513 | 0.84 | MAPT (0.59) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16769910 | 0.84 | MAPT (0.59) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16755511 | 0.84 | MAPT (0.59) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL16755520 | 0.84 | MAPT (0.62) | MAPTLMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884825-B2 | Curcumin analogs and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-9884825-B2 | Curcumin analogs and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | UNIVERSITY OF DELHI (IN) | 2015-06-04 | — | — | US | disclosed |
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | UNIVERSITY OF DELHI (IN) | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152056-A1 | Curcumin Analogs and Methods of Making and Using Thereof | COX15, HCCS, HMOX2 | MAPT 3159/4885LMNA 515/4885ALDH1A1 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.